[Preparation and anti-breast cancer activity of (-)-antofine carried with liposomes].

Abstract

OBJECTIVE:

To prepare (-)-Antofine liposomes with high activity and good water-soluble and study its anti-breast cancer activity both in vitro and in vivo.

METHODS:

(-)-Antofine liposomes were prepared by film dispersion method, the encapsulation efficiency of (-)-Antofine liposomes were determined by UV spectrophotometer, the cytotoxic activity of (-)-Antofine liposomes on MCF-7 cell was measured by MTT assay, the antitumor activity and major organs indexes were evaluated by tumor-bearing nude mice experimental in vivo.

RESULTS:

The average encapsulation efficiency of (-)-Antofine liposomes was (80.8 +/- 2.2)%, average drug loading was (26.7 +/- 1.4)%, it was relatively good water-soluble and had good anti-tumor activity in vitro and in vivo.

CONCLUSION:

(-)-Antofine liposomes prepared by film dispersion method has high encapsulation efficiency, the water-soluble and the anti-tumor activity are improved compared with (-)-Antofine.

• Authors: Duo-Ming Wu, Ying Chen, Li Wu
• Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials (Zhong Yao Cai) Vol. 36 Issue 9 Pg. 1511-4 (Sep 2013) ISSN: 1001-4454 [Print] China
• PMID: 24620699 (Publication Type: Journal Article)

Chemical References

• Antineoplastic Agents, Phytogenic
• Drug Carriers
• Indoles
• Liposomes
• Phenanthrolines
• antofine

Topics

• Animals
• Antineoplastic Agents, Phytogenic (administration & dosage, chemistry, pharmacology)
• Breast Neoplasms (pathology)
• Drug Carriers
• Drug Compounding (methods)
• Drug Stability
• Female
• Humans
• Indoles (administration & dosage, chemistry, pharmacology)
• Liposomes (chemistry)
• MCF-7 Cells
• Mice
• Mice, Nude
• Nanoparticles
• Particle Size
• Phenanthrolines (administration & dosage, chemistry, pharmacology)
• Solubility
• Xenograft Model Antitumor Assays