Abstract | PURPOSE: METHODS: We performed a crossover trial involving 16 adults with self-reported lactose intolerance and lactose malabsorption confirmed by hydrogen (H2) breath testing. Participants underwent 3, 8-day milk phases (raw vs 2 controls: pasteurized, soy) in randomized order separated by 1-week washout periods. On days 1 and 8 of each phase, milk consumption was 473 mL (16 oz); on days 2 to 7, milk dosage increased daily by 118 mL (4 oz), beginning with 118 mL (4 oz) on day 2 and reaching 710 mL (24 oz) on day 7. Outcomes were area under the breath H2 curve (AUC H2) and self-reported symptom severity (visual analog scales: flatulence/gas, audible bowel sounds, abdominal cramping, diarrhea). RESULTS: AUC H2 (mean ± standard error of the mean) was higher for raw vs pasteurized on day 1 (113 ± 21 vs 71 ± 12 ppm·min·10(-2), respectively, P = .01) but not day 8 (72 ± 14 vs 74 ± 15 ppm·min·10(-2), respectively, P = .9). Symptom severities were not different for raw vs pasteurized on day 7 with the highest dosage (P >.7). AUC H2 and symptom severities were higher for both dairy milks compared with soy milk. CONCLUSIONS:
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Authors | Sarah Mummah, Beibei Oelrich, Jessica Hope, Quyen Vu, Christopher D Gardner |
Journal | Annals of family medicine
(Ann Fam Med)
2014 Mar-Apr
Vol. 12
Issue 2
Pg. 134-41
ISSN: 1544-1717 [Electronic] United States |
PMID | 24615309
(Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Topics |
- Adult
- Animals
- Breath Tests
- Cattle
- Cross-Over Studies
- Double-Blind Method
- Humans
- Lactose Intolerance
(diet therapy)
- Milk
- Pasteurization
- Pilot Projects
- Severity of Illness Index
- Soy Milk
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