Abstract | PURPOSE: Evaluation of recurrences, complications and function at mid-term follow-up after curettage for sacral giant cell tumor (GCT). METHODS: We retrospectively studied all 26 patients treated for sacral GCT in the Netherlands (from 1990 to 2010). Median follow-up was 98 (6-229) months. All patients underwent intralesional excision, 21 with local adjuvants, 5 radiotherapy, 3 IFN-α, 1 bisphosphonates. Functional outcome was assessed using Musculoskeletal Tumor Society (MSTS) score. Statistics were performed with Kaplan-Meier, Cox regression, log rank and Mann-Whitney U. RESULTS: Recurrence rate was 14/26 after median 13 (3-139) months and was highest after isolated curettage (4/5). Soft tissue masses >10 cm increased recurrence risk (HR = 3.3, 95 % CI = 0.81-13, p = 0.09). Complications were reported in 12/26 patients. MSTS was superior in patients without complications (27 vs. 21; p = 0.024). CONCLUSION: Recurrence rate for sacral GCT was highest after isolated curettage, indicating that (local) adjuvant treatment is desired to obtain immediate local control. Complications were common and impaired function.
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Authors | L van der Heijden, M A J van de Sande, I C M van der Geest, H W B Schreuder, B J van Royen, P C Jutte, J A M Bramer, F C Öner, A P van Noort-Suijdendorp, H M Kroon, P D S Dijkstra |
Journal | European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society
(Eur Spine J)
Vol. 23
Issue 9
Pg. 1949-62
(Sep 2014)
ISSN: 1432-0932 [Electronic] Germany |
PMID | 24614982
(Publication Type: Journal Article)
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Chemical References |
- Bone Density Conservation Agents
- Diphosphonates
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Topics |
- Adolescent
- Adult
- Aged
- Bone Density Conservation Agents
(therapeutic use)
- Bone Neoplasms
(mortality, surgery, therapy)
- Chemoradiotherapy, Adjuvant
(methods)
- Curettage
- Diphosphonates
(therapeutic use)
- Female
- Follow-Up Studies
- Giant Cell Tumor of Bone
(mortality, surgery, therapy)
- Humans
- Kaplan-Meier Estimate
- Male
- Middle Aged
- Neoplasm Recurrence, Local
- Netherlands
- Postoperative Complications
(mortality)
- Retrospective Studies
- Risk Factors
- Sacrum
(surgery)
- Treatment Outcome
- Young Adult
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