Abstract | INTRODUCTION:
Gallbladder cancer has a poor prognosis, with a reported 5-year survival of 5%. The prognosis improves when an R0 resection is feasible, but an early diagnosis is rare. The aim of the present study is to analyze the different conditions associated with gallbladder carcinomas and to report the main prognostic factors for these tumors to enable prevention. MATERIALS AND METHODS: From 1986 to 2012, 75 patients were found to have gallbladder cancer during the study of 2942 patients affected by biliary tract diseases; 34 of these patients had gallbladder and gallstones, and had been subjected to bile analysis. Pancreatobiliary reflux was studied by biliary trypsin and C-Ki-ras genes were analyzed in 11 cases. RESULTS: DISCUSSION AND CONCLUSION:
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Authors | Andrea Cariati, Elisa Piromalli, Francesco Cetta |
Journal | European journal of gastroenterology & hepatology
(Eur J Gastroenterol Hepatol)
Vol. 26
Issue 5
Pg. 562-9
(May 2014)
ISSN: 1473-5687 [Electronic] England |
PMID | 24614695
(Publication Type: Journal Article, Multicenter Study)
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Chemical References |
- Antineoplastic Agents
- KRAS protein, human
- Proto-Oncogene Proteins
- Proto-Oncogene Proteins p21(ras)
- ras Proteins
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Topics |
- Aged
- Antineoplastic Agents
(therapeutic use)
- Bile Reflux
(epidemiology)
- Carcinoma
(epidemiology, genetics, pathology, prevention & control, therapy)
- Cholecystectomy
- Female
- Gallbladder Neoplasms
(epidemiology, genetics, pathology, prevention & control, therapy)
- Gallstones
(epidemiology)
- Genetic Predisposition to Disease
- Humans
- Italy
- Male
- Middle Aged
- Mutation
- Patient Selection
- Precision Medicine
- Proto-Oncogene Proteins
(genetics)
- Proto-Oncogene Proteins p21(ras)
- Risk Assessment
- Risk Factors
- Treatment Outcome
- ras Proteins
(genetics)
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