Class II versus Class III radical hysterectomy in early cervical cancer: an observational study in a tertiary center.

Abstract

AIMS:

The purpose of this observational study was to evaluate disease free survival (DFS), overall survival (OS), and local recurrence rate (LRR) in patients submitted to Class II RH compared with Class III RH in early FIGO stage cervical cancer (ECC).

MATERIALS AND METHODS:

We investigated 127 patients with CC admitted to the National Cancer Institute of Milan from June 2001 to October 2011 treated with Class II RH, and compared them with 202 patients operated with Class III RH between March 1980 and March 2001. A total of 329 patients were collected.

RESULTS:

Median follow-up time was 91 months (IQ range:58-196). Five-year OS and DFS estimates were 89.5% (95%CI: 86.0-93.2%) and 85.6% (95%CI: 81.6-89.7%), respectively. Estimates of effect of surgical treatment (Class III RH versus Class II RH) on OS showed a HR of death = 3.38 (95%CI: 1.18-9.63, P = 0.0228), at univariable Cox analysis, and a HR = 3.08 (95%CI: 0.96-9.93; P = 0.0595) at multivariable analysis. For DFS, a HR of relapse = 2.51 (95%CI 1.10-5.72; P = 0.0290) comparing Class III vs Class II was found at multivariable analysis. Overall recurrence rate was 12.8%, whilst it was 16.3% for Class III and 7.1% for Class II respectively.

CONCLUSIONS:

The present data suggest that the outcomes of Class II RH are comparable in terms of LRR and OS to those of Class III RH, according to literature data. The opportunity of extending the indication to all women with ECC needs further investigations. Clearer data are warranted by prospective controlled studies.

• Authors: A Ditto, F Martinelli, S Ramondino, S L Vullo, M Carcangiu, E Haeusler, L Mariani, D Lorusso, F Raspagliesi
• Journal: European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology (Eur J Surg Oncol) Vol. 40 Issue 7 Pg. 883-90 (Jul 2014) ISSN: 1532-2157 [Electronic] England
• PMID: 24613739 (Publication Type: Comparative Study, Journal Article, Observational Study)
• Copyright: Copyright © 2014 Elsevier Ltd. All rights reserved.

Topics

• Age Factors
• Biopsy, Needle
• Chi-Square Distribution
• Cohort Studies
• Disease-Free Survival
• Early Detection of Cancer
• Female
• Humans
• Hysterectomy (methods, mortality)
• Immunohistochemistry
• Italy
• Kaplan-Meier Estimate
• Multivariate Analysis
• Neoplasm Invasiveness (pathology)
• Neoplasm Recurrence, Local (mortality, pathology, therapy)
• Neoplasm Staging
• Prognosis
• Proportional Hazards Models
• Retrospective Studies
• Risk Assessment
• Survival Analysis
• Tertiary Care Centers
• Treatment Outcome
• Uterine Cervical Neoplasms (mortality, pathology, surgery)