Persistent presence of the anti-myelin oligodendrocyte glycoprotein autoantibody in a pediatric case of acute disseminated encephalomyelitis followed by optic neuritis.

Abstract

We report the case of a 5-year-old Japanese girl who initially had acute disseminated encephalomyelitis (ADEM) and was positive for the myelin oligodendrocyte glycoprotein (MOG) antibodies and developed unilateral optic neuritis (ON) 71 days after ADEM onset. The patient's serum was positive for the anti-MOG antibodies from the onset of ADEM to the development of ON. This phenotype has been reported in only two previous articles, and the specific mechanism of action of the anti-MOG antibodies is not yet understood. Our case suggests that the anti-MOG antibody can be associated with the pathogenesis of ADEM followed by ON. Thus, patients with ADEM who test positive for the anti-MOG antibody may be at risk of developing subsequent ON.

• Authors: Akihiko Miyauchi, Yukifumi Monden, Meri Watanabe, Hideo Sugie, Mitsuya Morita, Takeshi Kezuka, Mariko Momoi, Takanori Yamagata
• Journal: Neuropediatrics (Neuropediatrics) Vol. 45 Issue 3 Pg. 196-9 (Jun 2014) ISSN: 1439-1899 [Electronic] Germany
• PMID: 24610298 (Publication Type: Case Reports, Journal Article)
• Copyright: Georg Thieme Verlag KG Stuttgart · New York.

Chemical References

• Autoantibodies
• Myelin-Oligodendrocyte Glycoprotein

Topics

• Autoantibodies (blood)
• Brain (pathology)
• Child, Preschool
• Encephalomyelitis, Acute Disseminated (blood, etiology)
• Female
• Humans
• Magnetic Resonance Imaging
• Myelin-Oligodendrocyte Glycoprotein (immunology)
• Optic Neuritis (complications)