Melanin-related metabolites in urine of B16 melanoma-bearing mice.

Abstract

5-S-Cysteinyldopa (5-S-CD), a pheomelanin precursor, has been used as a biochemical marker of melanoma metastasis. Recently, 5-hydroxy-6-methoxyindole-2-carboxylic acid (5H6MI2C), a eumelanin-related metabolite, was shown to reflect well the degree of skin pigmentation. We measured the urinary excretion of 5H6MI2C and 5-S-CD in mice bearing B16 melanoma to determine which of the two markers better reflects the progression of melanoma. The urinary excretion of both 5H6MI2C and 5-S-CD increased rapidly in parallel with the tumour volume. The highest values for the two metabolites in melanoma-bearing mice were three orders of magnitude higher than those in control mice. However, 5H6MI2C had a higher excretion level at the early stage of melanoma progression, while 5-S-CD had a higher excretion level at the later stage.

• Authors: K Wakamatsu, S Ito, K Fujita
• Journal: Acta dermato-venereologica (Acta Derm Venereol) Vol. 68 Issue 5 Pg. 385-9 ( 1988) ISSN: 0001-5555 [Print] Sweden
• PMID: 2461020 (Publication Type: Journal Article)

Chemical References

• Biomarkers, Tumor
• Indoles
• Melanins
• Cysteinyldopa
• 5-hydroxy-6-methoxy-2-indolylcarboxylic acid
• 2-S-cysteinyldopa
• 6-hydroxy-5-methoxy-2-indolylcarboxylic acid
• Dihydroxyphenylalanine
• Dopamine

Topics

• Animals
• Biomarkers, Tumor (analysis)
• Cysteinyldopa (urine)
• Dihydroxyphenylalanine (analogs & derivatives)
• Dopamine (urine)
• Indoles (urine)
• Melanins (metabolism)
• Melanoma, Experimental (diagnosis, pathology, urine)
• Mice
• Mice, Inbred C57BL