Chemotherapy for Generalized Infantile Myofibromatosis With Visceral Involvement.

Abstract

Infantile myofibromatosis (IM) is most commonly limited to cutaneous lesions that resolve spontaneously. However, generalized IM with visceral involvement, which has a reported mortality rate as high as 73%, has been successfully treated with a combination of methotrexate and vinblastine. Here we report the further efficacy of low-dose methotrexate and vinblastine in 2 pediatric patients with IM and visceral involvement and review the literature describing chemotherapy for these patients.

• Authors: Susan Y Wu, Timothy L McCavit, Kevin Cederberg, Rene L Galindo, Patrick J Leavey
• Journal: Journal of pediatric hematology/oncology (J Pediatr Hematol Oncol) Vol. 37 Issue 5 Pg. 402-5 (Jul 2015) ISSN: 1536-3678 [Electronic] United States
• PMID: 24608078 (Publication Type: Case Reports, Journal Article)

Chemical References

• Antineoplastic Agents
• Vincristine
• Methotrexate

Topics

• Antineoplastic Agents (therapeutic use)
• Female
• Humans
• Infant
• Infant, Newborn
• Male
• Methotrexate (therapeutic use)
• Myofibromatosis (congenital, drug therapy, pathology)
• Vincristine (therapeutic use)
• Viscera (pathology)