Peliosis hepatis complicated by portal hypertension following renal transplantation.

Abstract

Peliosis hepatis (PH) is a vascular lesion of the liver that mimics a hepatic tumor. PH is often associated with underlying conditions, such as chronic infection and tumor malignancies, or with the use of anabolic steroids, immunosuppressive drugs, and oral contraceptives. Most patients with PH are asymptomatic, but some present with abdominal distension and pain. In some cases, PH may induce intraperitoneal hemorrhage and portal hypertension. This study analyzed a 46-year-old male who received a transplanted kidney nine years prior and had undergone long-term immunosuppressive therapy following the renal transplantation. The patient experienced progressive abdominal distention and pain in the six months prior to this study. Initially, imaging studies revealed multiple liver tumor-like abnormalities, which were determined to be PH by pathological analysis. Because the hepatic lesions were progressively enlarged, the patient suffered from complications related to portal hypertension, such as intense ascites and esophageal varices bleeding. Although the patient was scheduled to undergo liver transplantation, he suffered hepatic failure and died prior to availability of a donor organ.

• Authors: Chia-Ying Yu, Liang-Che Chang, Li-Wei Chen, Tsung-Shih Lee, Rong-Nan Chien, Ming-Fang Hsieh, Kun-Chun Chiang
• Journal: World journal of gastroenterology (World J Gastroenterol) Vol. 20 Issue 9 Pg. 2420-5 (Mar 07 2014) ISSN: 2219-2840 [Electronic] United States
• PMID: 24605041 (Publication Type: Case Reports, Journal Article)

Chemical References

• Immunosuppressive Agents

Topics

• Alcohol Drinking
• Ascites (etiology)
• Biopsy
• Esophageal and Gastric Varices (etiology)
• Fatal Outcome
• Gastrointestinal Hemorrhage (etiology)
• Humans
• Hypertension, Portal (diagnosis, etiology, physiopathology, surgery)
• Immunohistochemistry
• Immunosuppressive Agents (therapeutic use)
• Kidney Transplantation (adverse effects)
• Liver Transplantation
• Male
• Middle Aged
• Peliosis Hepatis (diagnosis, etiology, surgery)
• Risk Factors
• Time Factors
• Tomography, X-Ray Computed
• Waiting Lists