Skin necrosis: a rare complication of protein S deficiency.

Hereditary protein S deficiency is an autosomal dominant disorder leading to recurrent venous thrombosis and, less commonly, to arterial thrombosis. Cases of skin necrosis have been documented in patients with protein C or S deficiency while being treated with warfarin. We describe herein a patient with protein S deficiency who developed significant skin necrosis without being exposed to warfarin. She had a protracted clinical course resulting in gangrene and transmetatarsal amputation. Recognition of this rare complication and an earlyhematology referral may prevent dismal outcomes in patients with protein S deficiency.
AuthorsAshif Jethava, Thalia Mesologites, Syed Ali, Constantin A Dasanu
JournalConnecticut medicine (Conn Med) Vol. 78 Issue 1 Pg. 29-32 (Jan 2014) ISSN: 0010-6178 [Print] United States
PMID24600778 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Protein C
  • Female
  • Humans
  • Ischemic Attack, Transient (complications, epidemiology)
  • Middle Aged
  • Necrosis
  • Protein C (analysis)
  • Protein S Deficiency (complications, epidemiology)
  • Skin (pathology)
  • Skin Diseases, Vesiculobullous (epidemiology, etiology)
  • Smoking (epidemiology)

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