Abstract | PURPOSE: PATIENTS AND METHODS: A prospectively designed observational study in a pulmonary rehabilitation hospital of 100 (39 male) stable COPD inpatients with a mean forced expiratory volume in 1 second (FEV1) of 1.1 L (42% of predicted) and a mean age of 64 years, using polysomnography with transcutaneous measurement of carbon dioxide pressure increase (ΔPtcCO2). RESULTS: SH as defined by the American Academy of Sleep Medicine (AASM) was found in 15 of the subjects, seven of whom used LTOT. However, six had SH despite being normocapnic during the daytime (only one on LTOT). Subjects with SH had a greater ΔPtcCO2 increase from nonrapid eye movement (NREM) to rapid eye movement (REM) sleep stages compared to non-SH subjects (mean [standard deviation] between-groups difference =0.23(0.20) kPa, P<0.0005). Subjects with apnea/hypopnea index ≥15 (overlap, N=27) did not differ from those with COPD alone (AHI <5, N=25) in sleep ΔPtcCO2 or daytime PaCO2. A regression model with the variables FEV1, LTOT, and sleep maximum ΔPtcCO2 explained 56% of the variance in daytime PaCO2 (F(3, 94) =40.37, P<0.001). CONCLUSION: In stable COPD, SH as defined by the AASM was found both in normocapnic, non-LTOT subjects and in hypercapnic, LTOT-using subjects. Between-sleep-stage increase in ΔPtcCO2 was higher in subjects with SH. Overlap subjects did not differ from simple COPD subjects in sleep ΔPtcCO2 or daytime PaCO2.
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Authors | Nils Henrik Holmedahl, Britt Øverland, Ove Fondenes, Ivar Ellingsen, Jon Andrew Hardie |
Journal | International journal of chronic obstructive pulmonary disease
(Int J Chron Obstruct Pulmon Dis)
Vol. 9
Pg. 265-75
( 2014)
ISSN: 1178-2005 [Electronic] New Zealand |
PMID | 24600219
(Publication Type: Journal Article, Observational Study, Research Support, Non-U.S. Gov't)
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Chemical References |
- Biomarkers
- Carbon Dioxide
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Topics |
- Aged
- Aged, 80 and over
- Biomarkers
(blood)
- Blood Gas Monitoring, Transcutaneous
- Carbon Dioxide
(blood)
- Female
- Forced Expiratory Volume
- Humans
- Hypercapnia
(blood, diagnosis, etiology, physiopathology)
- Hypoventilation
(blood, diagnosis, etiology, physiopathology)
- Lung
(physiopathology)
- Male
- Middle Aged
- Partial Pressure
- Polysomnography
- Prospective Studies
- Pulmonary Disease, Chronic Obstructive
(blood, complications, diagnosis, physiopathology)
- Sleep
- Sleep Apnea Syndromes
(blood, diagnosis, etiology, physiopathology)
- Time Factors
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