HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Dabigatran etexilate for venous thromboembolism: a safety evaluation.

AbstractINTRODUCTION:
Recently, new oral anticoagulants (NOACs) have become available to treat thromboembolic disorders. The efficacy and safety of these agents have been thoroughly tested in various clinical trials. In this article, we discuss the evidence for the safety and efficacy of dabigatran in the prevention and treatment of venous thromboembolism (VTE).
AREAS COVERED:
We discuss the pharmacology of dabigatran and compare it to that of warfarin and two of the other popular NOACs, rivaroxaban and apixaban. The indications for and evidence behind dabigatran in the prevention of VTE are presented, as well as the trials examining its potential use for the treatment and extended treatment of VTE. We conclude by considering the safety aspects of the drug.
EXPERT OPINION:
For most patients the overall net clinical benefit would seem to be in favour of dabigatran. Both efficacy and safety have been proven in the setting of robust randomised controlled trials. 'Real world' registry data as well as long-term trial follow-up will add further critical information. Long-term experience might be one of the few advantages warfarin still has over dabigatran in patients who are eligible for both.
AuthorsRichard Brown, Gregory Yh Lip, Pilar Gallego
JournalExpert opinion on drug safety (Expert Opin Drug Saf) Vol. 13 Issue 5 Pg. 639-47 (May 2014) ISSN: 1744-764X [Electronic] England
PMID24598005 (Publication Type: Journal Article, Review)
Chemical References
  • Benzimidazoles
  • Factor Xa Inhibitors
  • Pyridines
  • Dabigatran
Topics
  • Benzimidazoles (adverse effects, pharmacokinetics, therapeutic use)
  • Contraindications
  • Dabigatran
  • Drug Interactions
  • Factor Xa Inhibitors (adverse effects, pharmacology, therapeutic use)
  • Humans
  • Pyridines (adverse effects, pharmacokinetics, therapeutic use)
  • Venous Thromboembolism (prevention & control)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: