Abstract |
Biocompatible lipo- histidine hybrid materials conjugated with IR820 dye show pH-sensitivity, efficient intracellular delivery of doxorubicin (Dox), and intrinsic targetability to cancer cells. These new materials form highly uniform Dox-loaded nanosized vesicles via a self-assembly process showing good stability under physiological conditions. The Dox-loaded micelles are effective for suppressing MCF-7 tumors, as demonstrated in vitro and in vivo. The combined mechanisms of the EPR effect, active internalization, endosomal-triggered release, and drug escape from endosomes, and a long blood circulation time, clearly prove that the IR820 lipopeptide DDS is a safe theranostic agent for imaging-guided cancer therapy.
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Authors | Renjith P Johnson, Young-Il Jeong, Johnson V John, Chung-Wook Chung, Seon Hee Choi, Song Yi Song, Dae Hwan Kang, Hongsuk Suh, Il Kim |
Journal | Macromolecular rapid communications
(Macromol Rapid Commun)
Vol. 35
Issue 9
Pg. 888-94
(May 2014)
ISSN: 1521-3927 [Electronic] Germany |
PMID | 24596253
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. |
Chemical References |
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Topics |
- Histidine
(chemistry)
- Humans
- Hydrogen-Ion Concentration
- MCF-7 Cells
- Microscopy, Electron, Transmission
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