Abstract | BACKGROUND:
Xylitol is a well-known anticaries agent and has been used for the prevention and treatment of dental caries. In this study, the anti-inflammatory effects of xylitol are evaluated for possible use in the prevention and treatment of periodontal infections. METHODS:
Cytokine expression was stimulated in THP-1 (human monocyte cell line)-derived macrophages by live Porphyromonas gingivalis, and enzyme-linked immunosorbent assay and a commercial multiplex assay kit were used to determine the effects of xylitol on live P. gingivalis-induced production of cytokine. The effects of xylitol on phagocytosis and the production of nitric oxide were determined using phagocytosis assay, viable cell count, and Griess reagent. The effects of xylitol on P. gingivalis adhesion were determined by immunostaining, and costimulatory molecule expression was examined by flow cytometry. RESULTS: CONCLUSION:
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Authors | Eunjoo Park, Hee Sam Na, Sheon Min Kim, Shannon Wallet, Seunghee Cha, Jin Chung |
Journal | Journal of periodontology
(J Periodontol)
Vol. 85
Issue 6
Pg. e212-23
(Jun 2014)
ISSN: 1943-3670 [Electronic] United States |
PMID | 24592909
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Anti-Inflammatory Agents
- CCL2 protein, human
- CXCL10 protein, human
- Chemokine CCL2
- Chemokine CXCL10
- Chemokines, CC
- Cytokines
- Immunodominant Epitopes
- Immunologic Factors
- Interleukin-1beta
- Macrophage Inflammatory Proteins
- P40, iodinated C-terminal peptide, human
- Peptide Fragments
- Tumor Necrosis Factor-alpha
- Interleukin-12
- Nitric Oxide
- Xylitol
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Topics |
- Anti-Inflammatory Agents
(pharmacology)
- Bacterial Adhesion
(drug effects)
- Cell Count
- Cell Line
- Cell Survival
(drug effects)
- Chemokine CCL2
(drug effects)
- Chemokine CXCL10
(drug effects)
- Chemokines, CC
(drug effects)
- Cytokines
(drug effects)
- Escherichia coli
(drug effects)
- Humans
- Immunodominant Epitopes
(drug effects)
- Immunologic Factors
(pharmacology)
- Interleukin-12
(analysis)
- Interleukin-1beta
(drug effects)
- Macrophage Inflammatory Proteins
(drug effects)
- Macrophages
(drug effects, microbiology)
- Monocytes
(immunology)
- Nitric Oxide
(analysis)
- Peptide Fragments
(drug effects)
- Phagocytosis
(drug effects)
- Porphyromonas gingivalis
(drug effects, immunology)
- Tumor Necrosis Factor-alpha
(drug effects)
- Xylitol
(pharmacology)
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