Expression of HMGB1 and NF-κB p65 and its significance in non-small cell lung cancer.

Abstract

AIM OF THE STUDY:

To study high mobility group protein B1 (HMGB1) and nuclear transcription factor p65 (NF-κB p65) expression in non-small cell lung cancer and its significance.

MATERIAL AND METHODS:

106 hospitalized patients with non-small cell lung cancer after thoracic surgery were enrolled; HMGB1 and p65 protein expression was detected by the immunohistochemical method. Semiquantitative expression of HMGB1 and NF-κB p65 was analyzed using Image Pro Plus (IPP) software and statistical analysis.

RESULTS:

The rate of HMGB1 positive expression in the non-small cell lung cancer protein B1 family was significantly higher than normal tissues (P < 0.05); p65 protein expression in the non-small cell lung carcinoma group was significantly higher than that of normal tissues (P < 0.05). HMGB1 and NF-κB p65 protein expression was significantly higher compared with the non-metastatic group (P < 0.01). HMGB1 and NF-κB p65 protein expression showed a positive correlation (P < 0.05).

CONCLUSIONS:

HMGB1 and NF-κB p65 expression may be related to non-small cell lung cancer metastasis.

• Authors: Xiaohong Zhang, Hongmin Wang, Jing Wang
• Journal: Contemporary oncology (Poznan, Poland) (Contemp Oncol (Pozn)) Vol. 17 Issue 4 Pg. 350-5 ( 2013) ISSN: 1428-2526 [Print] Poland
• PMID: 24592122 (Publication Type: Journal Article)