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Ligand screening using NMR.

Abstract
NMR has proven to be an invaluable technique for identifying and characterizing ligand interactions with biomolecules. NMR-based detection of ligand binding to protein targets is described. Specifically, the use of the WaterLOGSY NMR experiment to screen mixtures of compounds from a fragment library for binding to influenza H5 hemagglutinin is detailed.
AuthorsBenjamin E Ramirez, Aleksandar Antanasijevic, Michael Caffrey
JournalMethods in molecular biology (Clifton, N.J.) (Methods Mol Biol) Vol. 1140 Pg. 305-13 ( 2014) ISSN: 1940-6029 [Electronic] United States
PMID24590726 (Publication Type: Journal Article)
Chemical References
  • Hemagglutinin Glycoproteins, Influenza Virus
  • Ligands
  • hemagglutinin, avian influenza A virus
  • Water
Topics
  • Drug Evaluation, Preclinical
  • Hemagglutinin Glycoproteins, Influenza Virus (chemistry)
  • Humans
  • Influenza, Human (genetics, metabolism)
  • Ligands
  • Magnetic Resonance Spectroscopy
  • Molecular Biology (methods)
  • Protein Binding
  • Water (chemistry)

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