Abstract |
D-Phenylalanyl-L-prolyl- L-arginine aldehyde sulfate (RGH-2958), a directly acting synthetic thrombin inhibitor proved to be effective by experimental oral application. The rapid onset of its action has a special importance both from theoretical and practical point of view. Its antiplatelet effect relates to thrombin induced PA and runs parallel with the anticoagulant effect. RGH-2958 significantly reduced the thrombus weight in an experimental thrombosis model in rabbits. In the light of the therapeutic indices of the compound there is a real possibility to open a third way in the prevention and therapy of thrombosis.
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Authors | D Bagdy, E Barabás, Z Fittler, E Orbán, G Rabloczky, S Bajusz, E Széll |
Journal | Folia haematologica (Leipzig, Germany : 1928)
(Folia Haematol Int Mag Klin Morphol Blutforsch)
Vol. 115
Issue 1-2
Pg. 136-40
( 1988)
ISSN: 0323-4347 [Print] Germany |
PMID | 2459008
(Publication Type: Journal Article)
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Chemical References |
- Oligopeptides
- H-D-Phe-Pro-arginal
- Thrombin
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Topics |
- Administration, Oral
- Animals
- Bile
(metabolism)
- Blood Coagulation Tests
- Dogs
- Drug Stability
- Duodenum
(metabolism)
- Gastric Juice
(metabolism)
- Intestinal Absorption
- Oligopeptides
(administration & dosage, pharmacokinetics)
- Rabbits
- Thrombin
(antagonists & inhibitors)
- Thrombosis
(blood)
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