[Interferon-inducing and immunostimulating activity of bonafton in an experiment].

Abstract

It was shown for the first time that the antiviral drug bonafton administered orally to nonlinear albino mice in single doses of 5, 12.5 and 25 mg/kg induced production of interferon in the animal blood serum. The maximum interferon titer of 160-320 IU/ml was observed 18 hours after the drug administration in a dose of 12.5 mg/kg. In low doses of 5 to 12.5 mg/kg bonafton increased the nonspecific resistance of the mice to experimental viral infections when administered orally in single doses not earlier than 2 weeks prior to the contamination. The ability of the drug to stimulate the host protective forces probably plays a certain role in the mechanism of its therapeutic action in severe viral infections of man such as severe recurring ophthalmic herpes, genital herpes, Behçet's disease, Melkersson-Rosenthal syndrome and others.

• Authors: I S Nikolaeva, A N Fomina
• Journal: Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic] (Antibiot Khimioter) Vol. 33 Issue 6 Pg. 455-9 (Jun 1988) ISSN: 0235-2990 [Print] Russia (Federation)
• Vernacular Title: Izuchenie interferonindutsiruiushcheĭ i immunostimuliruiushcheĭ aktivnosti bonaftona v éksperimente.
• PMID: 2458705 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Adjuvants, Immunologic
• Antiviral Agents
• Interferon Inducers
• Naphthoquinones
• bonafton
• Interferons

Topics

• Adjuvants, Immunologic
• Animals
• Antiviral Agents (therapeutic use)
• Dose-Response Relationship, Drug
• Drug Evaluation, Preclinical
• Immunity, Innate (drug effects)
• Interferon Inducers
• Interferons (blood)
• Mice
• Naphthoquinones (therapeutic use)
• Time Factors
• Virus Diseases (blood, drug therapy, immunology)