Abstract | BACKGROUND: AIM: To investigate the effects of palm TRF supplementation on hepatic bilirubin-metabolizing enzymes and oxidative stress status in rats administered phenylhydrazine. METHODS: Twenty-four male Wistar rats were divided into two groups; one group was intraperitoneally injected with palm TRF at the dose of 30 mg/kg/day, while another group was only given vehicle (control) ( vitamin E-free palm oil) for 14 days. Twenty-four hours after the last dose, each group was further subdivided into another two groups. One group was administered phenylhydrazine (100 mg/kg, intraperitoneally) and another group was administered normal saline. Twenty-four hours later, blood and liver were collected for biochemical parameter measurements. RESULTS: CONCLUSION:
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Authors | Yusof Kamisah, Jing Jye Lim, Chew-Lian Lim, Ahmad Y Asmadi |
Journal | PloS one
(PLoS One)
Vol. 9
Issue 2
Pg. e89248
( 2014)
ISSN: 1932-6203 [Electronic] United States |
PMID | 24586630
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antioxidants
- Phenylhydrazines
- Plant Oils
- Tocotrienols
- phenylhydrazine
- Heme Oxygenase (Decyclizing)
- Oxidoreductases Acting on CH-CH Group Donors
- biliverdin reductase
- Glucuronosyltransferase
- Bilirubin
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Topics |
- Animals
- Antioxidants
(pharmacology)
- Bilirubin
(metabolism)
- Cycas
(chemistry)
- Dietary Supplements
- Erythrocytes
(drug effects, metabolism)
- Glucuronosyltransferase
(metabolism)
- Heme Oxygenase (Decyclizing)
(metabolism)
- Hyperbilirubinemia
(drug therapy, metabolism, pathology)
- Lipid Peroxidation
(drug effects)
- Liver
(drug effects, metabolism)
- Male
- Oxidative Stress
(drug effects)
- Oxidoreductases Acting on CH-CH Group Donors
(metabolism)
- Phenylhydrazines
(toxicity)
- Plant Oils
(pharmacology)
- Rats
- Rats, Wistar
- Tocotrienols
(pharmacology)
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