Management of recurrent alveolar soft-part sarcoma of the tongue after external beam radiotherapy with iodine-125 seed brachytherapy.

Abstract

BACKGROUND:

Alveolar soft part sarcoma (ASPS) is a rare type of soft tissue sarcoma. The infrequency of ASPS is such that it accounts for <1% of all soft tissue sarcomas and <0.1% of sarcomas concerning the head and neck, primarily those involving the orbit (48%) and tongue (25%). Traditional chemotherapy or radiotherapy of ASPS is often associated with poor outcome, even after comprehensive interventions.

METHODS AND RESULTS:

We performed iodine-125 ((125) I) seed brachytherapy under ultrasound guidance through a submandibular puncture in a 4-year-old boy with recurrent ASPS of the tongue. The prescription dose was 120 Gy; therefore, 35 (125) I seeds were implanted with 0.77 mCi per seed, the total amount of activity being 26.95 mCi. CT scans confirmed a complete response after the treatment.

CONCLUSION:

Our patient now has a recurrent-free survival of >30 months, an amount of time longer than the median rate described in the literature.

• Authors: Na Meng, Xiaomeng Zhang, Anyan Liao, Suqing Tian, Weiqiang Ran, Yang Gao, Jun Jie Wang
• Journal: Head & neck (Head Neck) Vol. 36 Issue 12 Pg. E125-8 (Dec 2014) ISSN: 1097-0347 [Electronic] United States
• PMID: 24585519 (Publication Type: Case Reports, Journal Article)
• Copyright: © 2014 Wiley Periodicals, Inc.

Chemical References

• Iodine Radioisotopes

Topics

• Brachytherapy
• Child, Preschool
• Humans
• Iodine Radioisotopes (administration & dosage)
• Male
• Neoplasm Recurrence, Local (diagnosis, radiotherapy)
• Sarcoma, Alveolar Soft Part (diagnosis, radiotherapy)
• Tongue Neoplasms (diagnosis, radiotherapy)