Eosinophilic inflammation of chronic rhinosinusitis with nasal polyps is related to OX40 ligand expression.

Abstract

The aims of this study were to investigate OX40 ligand expression in sinus tissue from patients with nasal polyposis compared with patients with chronic rhinosinusitis without nasal polyps (NPs), and to determine if OX40 ligand expression is related to eosinophilic sinus infiltration. Twenty patients with chronic rhinosinusitis (11 with and nine without NPs) and seven controls were enrolled in the study. The mRNA expression of OX40 ligand and thymic stromal lymphopoietin and its receptor were analyzed. The immunoreactivity score for OX40 ligand and the eosinophil count were obtained. The mRNA expression and immunoreactivity score of OX40 ligand were higher in patients with nasal polyposis than in patients without NPs, as well as healthy controls. The mRNA expression of thymic stromal lymphopoietin and its receptor was significantly higher in nasal polyposis than in the control, but not significantly higher than in chronic rhinosinusitis without NPs. A correlation between the number of OX40 ligand-positive cells and the number of eosinophils in sinus biopsies was found only in patients with nasal polyposis. In conclusion, the thymic stromal lymphopoietin/OX40 ligand axis is up-regulated in nasal polyposis and is related to the intensity of eosinophilic inflammation.

• Authors: Monica Boita, Massimiliano Garzaro, Luca Raimondo, Giuseppe Riva, Jasenka Mazibrada, Giancarlo Pecorari, Caterina Bucca, Graziella Bellone, Barbara Vizio, Enrico Heffler, Fabio Luigi Ricciardolo, Giovanni Rolla
• Journal: Innate immunity (Innate Immun) Vol. 21 Issue 2 Pg. 167-74 (Feb 2015) ISSN: 1753-4267 [Electronic] United States
• PMID: 24583911 (Publication Type: Journal Article)
• Copyright: © The Author(s) 2014 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav.

Chemical References

• CRLF2 protein, human
• Cytokines
• OX40 Ligand
• Receptors, Cytokine
• Thymic Stromal Lymphopoietin

Topics

• Adult
• Aged
• Aged, 80 and over
• Cell Movement
• Chronic Disease
• Cytokines (genetics, metabolism)
• Eosinophils (immunology)
• Female
• Humans
• Inflammation (pathology)
• Male
• Middle Aged
• Nasal Polyps (complications, immunology)
• OX40 Ligand (genetics, metabolism)
• Paranasal Sinuses (metabolism, pathology)
• Receptors, Cytokine (genetics, metabolism)
• Rhinitis (complications, immunology)
• Sinusitis (complications, immunology)
• Thymic Stromal Lymphopoietin