Abstract | PURPOSE: METHODS: Forty-seven male Sprague-Dawley rats were subjected to 7 min of CA and 3 min of cardiopulmonary resuscitation ( CPR). In protocol I animals were randomized to receive either 70% or 40% argon ventilation 1 h after successful CPR or no argon-treatment. Animals of the second protocol also received 1 h of 70% argon ventilation or no argon treatment but were randomized to a group receiving the K( ATP) channel blocker 5-hydroxydecanoate (5-HD). For all animals a neurological deficit score ( NDS) was calculated daily for seven days following the experiment before the animals were killed and the brains harvested for histopathological analyses. RESULTS: All animals survived. Control animals exhibited severe neurologic dysfunction at all points in time as measured with the NDS. Argon treated animals showed significant improvements in the NDS through all postoperative days in a dose dependent fashion. This was paralleled by a significant reduction in the neuronal damage index in the neocortex and the hippocampal CA 3/4 region. Administration of 5-HD neither abolished the positive effects on functional recovery nor on histopathologic changes observed in the argon group. CONCLUSION:
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Authors | Anne Brücken, Pinar Kurnaz, Christian Bleilevens, Matthias Derwall, Joachim Weis, Kay Nolte, Rolf Rossaint, Michael Fries |
Journal | Resuscitation
(Resuscitation)
Vol. 85
Issue 6
Pg. 826-32
(Jun 2014)
ISSN: 1873-1570 [Electronic] Ireland |
PMID | 24582739
(Publication Type: Journal Article)
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Copyright | Copyright © 2014 Elsevier Ireland Ltd. All rights reserved. |
Chemical References |
- KATP Channels
- Neuroprotective Agents
- Argon
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Topics |
- Animals
- Argon
(administration & dosage)
- Brain Diseases
(etiology, prevention & control)
- Disease Models, Animal
- Dose-Response Relationship, Drug
- Heart Arrest
(complications)
- KATP Channels
(physiology)
- Male
- Neuroprotective Agents
(administration & dosage)
- Rats
- Rats, Sprague-Dawley
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