[Effect of low-molecular interferon inducers in experimental hepatitis in mice].

Abstract

Among low molecular interferon inducers preparations were selected which were capable of inducing interferon (IFN) synthesis after oral administration and advantageous for further clinical use. The dynamics of interferon production was studied after oral administration of three national low molecular interferon inducers. The selected preparations: a synthetic inducer, amiksin, and 2 natural compounds (gossypol derivatives), kagocel-1 and PXL-6, stimulated high levels of interferon production (from 10,000 to 20,000 IU/ml) in the intestinal tract of the animals 4 hours after induction and protected the animals from hepatitis virus of mice (the Meshcherin strain) after oral administration 24 hours before infection (35-55%). Amiksin and PXL-6 produced significant protection (p less than 0.01 or 0.001)--40 or 50%, respectively, when administered 4 hours before virus infection.

• Authors: E B Tazulakhova, A M Saĭitkulov, I F Barinskiĭ, F I Ershov
• Journal: Voprosy virusologii (Vopr Virusol) 1988 Mar-Apr Vol. 33 Issue 2 Pg. 179-81 ISSN: 0507-4088 [Print] Russia (Federation)
• Vernacular Title: Effekt nizkomolekuliarnykh induktorov interferona pri éksperimental'nom gepatite mysheĭ.
• PMID: 2457987 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Interferon Inducers
• Organic Chemicals
• cagocel-1
• PXL 6
• Interferons
• Gossypol
• Tilorone

Topics

• Animals
• Drug Evaluation, Preclinical
• Gossypol (analogs & derivatives, therapeutic use)
• Hepatitis, Viral, Animal (drug therapy)
• Interferon Inducers (therapeutic use)
• Interferons (analysis)
• Mice
• Mice, Inbred CBA
• Molecular Weight
• Murine hepatitis virus
• Organic Chemicals
• Tilorone (analogs & derivatives, therapeutic use)
• Time Factors