Possible proarrhythmic effects of tocainide in dilated cardiomyopathy.

Abstract

A patient with a dilated cardiomyopathy experienced a cardiac arrest when taking tocainide for asymptomatic nonsustained ventricular tachycardia. After successful resuscitation from ventricular fibrillation and exclusion of a myocardial infarction, an electrophysiological evaluation was performed. Drug-free study #1 revealed no induction of ventricular tachycardia. A tocainide study revealed induction of sustained monomorphic ventricular tachycardia. Drug-free study #2 revealed induction of nonsustained ventricular tachycardia. This report illustrates a possible proarrhythmic effect of tocainide.

• Authors: S L Brownstein, L Constantin, M G Kienzle, J B Martins
• Journal: Pacing and clinical electrophysiology : PACE (Pacing Clin Electrophysiol) Vol. 11 Issue 7 Pg. 1032-5 (Jul 1988) ISSN: 0147-8389 [Print] United States
• PMID: 2457881 (Publication Type: Case Reports, Journal Article)

Chemical References

• Tocainide
• Lidocaine

Topics

• Cardiomyopathy, Dilated (drug therapy)
• Heart Arrest (chemically induced)
• Humans
• Lidocaine (adverse effects, analogs & derivatives, therapeutic use)
• Male
• Middle Aged
• Tachycardia (chemically induced)
• Tocainide