Abstract | UNLABELLED: METHODS: Biodistribution, dosimetry and tumor uptake of the GRPr antagonist ⁶⁴Cu-CB-TE2A-AR06 [(⁶⁴Cu-4,11-bis(carboxymethyl)-1,4,8,11-tetraazabicyclo(6.6.2) hexadecane)-PEG₄-D-Phe-Gln-Trp-Ala-Val- Gly-His-Sta-LeuNH₂] were studied by PET/CT in four patients with newly diagnosed prostate cancer (T1c-T2b, Gleason 6-7). RESULTS: No adverse events were observed after injection of ⁶⁴Cu-CB-TE2A-AR06. Three of four tumors were visualized with high contrast [ tumor-to-prostate ratio > 4 at 4 hours (h) post injection (p.i.)], one small tumor (T1c, < 5% tumor on biopsy specimens) showed moderate contrast ( tumor-to-prostate ratio at 4 h: 1.9). Radioactivity was cleared by the kidneys and only the pancreas demonstrated significant accumulation of radioactivity, which rapidly decreased over time. CONCLUSION:
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Authors | Gesche Wieser, Rosalba Mansi, Anca L Grosu, Wolfgang Schultze-Seemann, Rebecca A Dumont-Walter, Philipp T Meyer, Helmut R Maecke, Jean Claude Reubi, Wolfgang A Weber |
Journal | Theranostics
(Theranostics)
Vol. 4
Issue 4
Pg. 412-9
( 2014)
ISSN: 1838-7640 [Electronic] Australia |
PMID | 24578724
(Publication Type: Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- (4,11-bis(carboxymethyl)-1,4,8,11-tetraazabicyclo(6.6.2)hexadecane)copper(II)
- (64Cu-4,11-bis(carboxymethyl)-1,4,8,11-tetraazabicyclo(6.6.2)hexadecane)-PEG4-phenylalanyl-glutaminyl-tryptophyl-alanyl-valyl-glycyl-histidyl-4-amino-3-hydroxy-6-methylheptanoyl-leucinamide
- Contrast Media
- Coordination Complexes
- Oligopeptides
- Organometallic Compounds
- Receptors, Bombesin
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Topics |
- Aged
- Contrast Media
- Coordination Complexes
(pharmacokinetics)
- Humans
- Kidney
(drug effects)
- Male
- Middle Aged
- Oligopeptides
(pharmacokinetics)
- Organometallic Compounds
(pharmacokinetics)
- Pancreas
(drug effects)
- Positron-Emission Tomography
(methods)
- Prostatic Neoplasms
(diagnosis)
- Receptors, Bombesin
(antagonists & inhibitors)
- Tissue Distribution
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