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Association between single nucleotide polymorphism rs1044925 and the risk of coronary artery disease and ischemic stroke.

Abstract
The present study was performed to clarify the association between the acyl-CoA:cholesterol acyltransferase-1 (ACAT-1) single nucleotide polymorphism (SNP) rs1044925 and the risk of coronary artery disease (CAD) and ischemic stroke (IS) in the Guangxi Han population. Polymerase chain reaction and restriction fragment length polymorphism was performed to determine the genotypes of the ACAT-1 SNP rs1044925 in 1730 unrelated subjects (CAD, 587; IS, 555; and healthy controls; 588). The genotypic and allelic frequencies of rs1044925 were significantly different between the CAD patients and controls (p = 0.015) and borderline different between the IS patients and controls (p = 0.05). The AC/CC genotypes and C allele were associated with a decreased risk of CAD and IS (CAD: p = 0.014 for AC/CC vs. AA, p = 0.022 for C vs. A; IS: p = 0.014 for AC/CC vs. AA; p = 0.017 for C vs. A). The AC/CC genotypes in the healthy controls, but not in CAD or IS patients, were associated with an increased serum high-density lipoprotein cholesterol (HDL-C) concentration. The present study shows that the C allele carriers of ACAT-1 rs1044925 were associated with an increased serum HDL-C level in the healthy controls and decreased risk in CAD and IS patients.
AuthorsDong-Feng Wu, Rui-Xing Yin, Xiao-Li Cao, Wu-Xian Chen
JournalInternational journal of molecular sciences (Int J Mol Sci) Vol. 15 Issue 3 Pg. 3546-59 (Feb 26 2014) ISSN: 1422-0067 [Electronic] Switzerland
PMID24577316 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Cholesterol, HDL
  • Lipids
  • ACAT1 protein, human
  • Acetyl-CoA C-Acetyltransferase
Topics
  • Acetyl-CoA C-Acetyltransferase (genetics)
  • Aged
  • Brain Ischemia (complications)
  • Cholesterol, HDL (blood)
  • Coronary Artery Disease (blood, genetics)
  • Gene Frequency
  • Genetic Predisposition to Disease (genetics)
  • Genotype
  • Humans
  • Lipids (blood)
  • Logistic Models
  • Male
  • Middle Aged
  • Multivariate Analysis
  • Polymerase Chain Reaction
  • Polymorphism, Restriction Fragment Length
  • Polymorphism, Single Nucleotide
  • Risk Factors
  • Stroke (blood, etiology, genetics)

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