Effect of Ramadan fasting on serum concentration of apelin-13 and new obesity indices in healthy adult men.

Abstract

BACKGROUND:

The aim of this study was to determine how Ramadan fasting (RF) affected the recently described new obesity indices [visceral adiposity index (VAI), waist circumference to height ratio (WHtR), body adiposity index (BAI)], and serum concentration of apelin-13 (RF) in healthy adult men.

MATERIAL AND METHODS:

For this purpose, 42 healthy adult men were selected. Anthropometric parameters were measured and a sample of venous blood was obtained for biochemical assays on the first and last days of Ramadan. When all subjects were evaluated, all anthropometric parameters changed except VAI. Serum apelin-13, triglyceride (TG), HDL-cholesterol (HDL-C), and insulin levels did not change. When patients were divided into 3 groups according to body mass index (BMI), BAI decreased in normal-weight subjects and WHtR decreased in other groups, but VAI and apelin-13 did not change in any groups.

RESULTS:

We demonstrate for the first time that while some anthropometric parameters changed, VAI and serum apelin-13 levels did not change with RF. BMI, waist circumference (WC), TG, and HDL-C were evaluated together in calculation of VAI. TG, VAI, and HDL-C remained unchanged by RF. Even if body weight (BW) and BMI decreased, apelin-13 was not affected by RF. The data on serum apelin-13 may have been influenced by the small-percentage decrease in BW, as well as insignificant improvements in metabolic parameters such as lipid profiles, glucose, and insulin.

CONCLUSIONS:

We found that Ramadan fasting in healthy adult men was associated with significant decreases in BW, BMI, WHtR, and BAI, but we found no significant changes in VAI and serum apelin-13 concentrations.

• Authors: Ahmet Celik, Edibe Saricicek, Vahap Saricicek, Elif Sahin, Gokhan Ozdemir, Selim Bozkurt, Mehmet Okumus, Mustafa Haki Sucakli, Gurkan Cikim, Yasemin Coskun, Mustafa Saygin Deniz, Ekrem Dogan, Metin Kilinc
• Journal: Medical science monitor : international medical journal of experimental and clinical research (Med Sci Monit) Vol. 20 Pg. 337-42 (Feb 28 2014) ISSN: 1643-3750 [Electronic] United States
• PMID: 24576923 (Publication Type: Journal Article)

Chemical References

• APLN protein, human
• Apelin
• Cholesterol, HDL
• Intercellular Signaling Peptides and Proteins

Topics

• Adiposity (physiology)
• Adult
• Apelin
• Body Mass Index
• Cholesterol, HDL (blood)
• Fasting (blood)
• Humans
• Intercellular Signaling Peptides and Proteins (blood)
• Intra-Abdominal Fat (metabolism)
• Islam
• Male
• Turkey
• Waist-Height Ratio