Abstract | BACKGROUND: METHODS: YKL-40 was measured in matched samples of BAL, serum and urine obtained from 36 infants and young children with CF participating in an early surveillance program. Levels were compared to clinical data and markers of inflammation detected in the lung. RESULTS: YKL-40 in BAL correlated with pulmonary infection [β=1.30 (SE 0.34), p < 0.001] and BAL markers of inflammation [macrophage number: r2 = 0.34, p < 0.001; neutrophil number: r2 = 0.74, p < 0.001; neutrophil elastase: r2 = 0.47, p < 0.001; CXCL8: r2 = 0.45, p < 0.001; IL-β: r2 = 0.62, p < 0.001]. YKL-40 was detectable in serum but levels did not correlate with BAL levels in the same individuals (r2 = 0.04, p = 0.14) or with inflammatory markers. YKL-40 was below the limit of detection in urine (30 pg/ml). CONCLUSIONS:
|
Authors | Emmanuelle Fantino, Catherine L Gangell, Dominik Hartl, Peter D Sly, AREST CF |
Journal | BMC pulmonary medicine
(BMC Pulm Med)
Vol. 14
Pg. 28
(Feb 27 2014)
ISSN: 1471-2466 [Electronic] England |
PMID | 24576297
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
Chemical References |
- Adipokines
- Biomarkers
- CHI3L1 protein, human
- Chitinase-3-Like Protein 1
- Lectins
|
Topics |
- Adipokines
(analysis, blood, urine)
- Biomarkers
(analysis)
- Bronchoalveolar Lavage Fluid
(chemistry)
- Child, Preschool
- Chitinase-3-Like Protein 1
- Cystic Fibrosis
(complications, immunology)
- Female
- Humans
- Inflammation
(etiology)
- Lectins
(analysis, blood, urine)
- Male
- Neutrophils
|