Sustained high levels of serum leptin rather than IL-6 observed in patients with postpartum thyroiditis during their first postpartum year.

Abstract

The purpose of the study is to explore the roles of leptin and interleukin-6 (IL-6) during the first postpartum year in the occurrence and development of postpartum thyroiditis (PPT). We retrospectively collected serum samples from 57 PPT patients consisting of 34 overt PPT (O-PPT) and 23 subclinical PPT (S-PPT) in addition to 37 healthy postpartum women at four postpartum time points, i.e., 3-day and 3, 6, 12-month postpartum. Serum leptin and IL-6 levels were measured by radioimmunoassay and ELISA assay, respectively. Leptin level and leptin/BMI (LEP/BMI) ratio were higher in PPT patients than in control during the first postpartum year, but were not significantly different between O-PPT and S-PPT. However, a similar trend but did not reach significant difference in IL-6 level was observed during the postpartum period in PPT patients and control women. We conclude that a sustained high level of serum leptin after delivery may be involved in the pathogenesis of PPT. IL-6 does not contribute to the development of PPT.

• Authors: Huiling Guo, Xiu Liu, Chenyang Li, Yushu Li, Miao Sang, Zhongyan Shan, Weiping Teng, Haixia Guan
• Journal: Endocrine (Endocrine) Vol. 47 Issue 2 Pg. 512-8 (Nov 2014) ISSN: 1559-0100 [Electronic] United States
• PMID: 24573491 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Interleukin-6
• Leptin

Topics

• Adult
• Female
• Humans
• Interleukin-6 (blood)
• Leptin (blood)
• Postpartum Period (blood)
• Postpartum Thyroiditis (blood)
• Retrospective Studies