Abstract | PURPOSE OF REVIEW: RECENT FINDINGS: Hotspot mutations in IDH isoforms 1 or 2 occur in approximately 15% of intrahepatic cholangiocarcinomas. These mutations result in elevated levels of an oncometabolite, 2-hydroxyglutarate, which is associated with higher DNA CpG methylation and altered histone methylation that accompany a block in cellular differentiation. Exploratory studies have suggested additional phenotypes associated with IDH1/2 mutations. SUMMARY:
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Authors | Alexandra R Grassian, Raymond Pagliarini, Derek Y Chiang |
Journal | Current opinion in gastroenterology
(Curr Opin Gastroenterol)
Vol. 30
Issue 3
Pg. 295-302
(May 2014)
ISSN: 1531-7056 [Electronic] United States |
PMID | 24569570
(Publication Type: Journal Article, Review)
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Chemical References |
- Glutarates
- alpha-hydroxyglutarate
- IDH2 protein, human
- Isocitrate Dehydrogenase
- IDH1 protein, human
- Prolyl Hydroxylases
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Topics |
- Bile Duct Neoplasms
(genetics, pathology)
- Bile Ducts, Intrahepatic
- Cell Differentiation
(genetics)
- Cholangiocarcinoma
(genetics, pathology)
- DNA Methylation
- Glutarates
(metabolism)
- Humans
- Isocitrate Dehydrogenase
(genetics)
- Mutation
- Prolyl Hydroxylases
(metabolism)
- Signal Transduction
(genetics)
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