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Scavenger receptor class B type I and immune dysfunctions.

AbstractPURPOSE OF REVIEW:
To summarize the recent findings about the roles of scavenger receptor class B type I (SR-BI) in immunity and discuss the underlying mechanisms by which SR-BI prevents immune dysfunctions.
RECENT FINDINGS:
SR-BI is well known as a high-density lipoprotein (HDL) receptor playing key roles in HDL metabolism and in protection against atherosclerosis. Recent studies have indicated that SR-BI is also an essential modulator in immunity. SR-BI deficiency in mice causes immune dysfunctions, including increased atherosclerosis, elevated susceptibility to sepsis, impaired lymphocyte homeostasis, and autoimmune disorders. SR-BI exerts its protective roles through a variety of HDL-dependent and HDL-independent mechanisms. SR-BI is also involved in hepatitis C virus cell entry. A deficiency of SR-BI in humanized mice has been shown to decrease hepatitis C virus infectivity.
SUMMARY:
SR-BI regulates immunity via multiple mechanisms and its deficiency causes numerous diseases. A comprehensive understanding of the roles of SR-BI in protection against immune dysfunctions may provide a therapeutic target for intervention against its associated diseases.
AuthorsZhong Zheng, Junting Ai, Xiang-An Li
JournalCurrent opinion in endocrinology, diabetes, and obesity (Curr Opin Endocrinol Diabetes Obes) Vol. 21 Issue 2 Pg. 121-8 (Apr 2014) ISSN: 1752-2978 [Electronic] England
PMID24569553 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Review)
Chemical References
  • Lipoproteins, HDL
  • Receptors, Lipoprotein
  • Scavenger Receptors, Class B
  • high density lipoprotein receptors
Topics
  • Adaptive Immunity
  • Animals
  • Atherosclerosis (immunology, metabolism)
  • Autoimmune Diseases (immunology, metabolism, prevention & control)
  • Cell Proliferation
  • Disease Models, Animal
  • Humans
  • Lipoproteins, HDL (immunology)
  • Mice
  • Mice, Knockout
  • Oxidative Stress (immunology)
  • Receptors, Lipoprotein (immunology)
  • Scavenger Receptors, Class B (deficiency, immunology)
  • Sepsis (immunology, metabolism)

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