Abstract | PURPOSE OF REVIEW: To summarize the recent findings about the roles of scavenger receptor class B type I (SR-BI) in immunity and discuss the underlying mechanisms by which SR-BI prevents immune dysfunctions. RECENT FINDINGS: SR-BI is well known as a high-density lipoprotein ( HDL) receptor playing key roles in HDL metabolism and in protection against atherosclerosis. Recent studies have indicated that SR-BI is also an essential modulator in immunity. SR-BI deficiency in mice causes immune dysfunctions, including increased atherosclerosis, elevated susceptibility to sepsis, impaired lymphocyte homeostasis, and autoimmune disorders. SR-BI exerts its protective roles through a variety of HDL-dependent and HDL-independent mechanisms. SR-BI is also involved in hepatitis C virus cell entry. A deficiency of SR-BI in humanized mice has been shown to decrease hepatitis C virus infectivity. SUMMARY: SR-BI regulates immunity via multiple mechanisms and its deficiency causes numerous diseases. A comprehensive understanding of the roles of SR-BI in protection against immune dysfunctions may provide a therapeutic target for intervention against its associated diseases.
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Authors | Zhong Zheng, Junting Ai, Xiang-An Li |
Journal | Current opinion in endocrinology, diabetes, and obesity
(Curr Opin Endocrinol Diabetes Obes)
Vol. 21
Issue 2
Pg. 121-8
(Apr 2014)
ISSN: 1752-2978 [Electronic] England |
PMID | 24569553
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Review)
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Chemical References |
- Lipoproteins, HDL
- Receptors, Lipoprotein
- Scavenger Receptors, Class B
- high density lipoprotein receptors
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Topics |
- Adaptive Immunity
- Animals
- Atherosclerosis
(immunology, metabolism)
- Autoimmune Diseases
(immunology, metabolism, prevention & control)
- Cell Proliferation
- Disease Models, Animal
- Humans
- Lipoproteins, HDL
(immunology)
- Mice
- Mice, Knockout
- Oxidative Stress
(immunology)
- Receptors, Lipoprotein
(immunology)
- Scavenger Receptors, Class B
(deficiency, immunology)
- Sepsis
(immunology, metabolism)
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