Complementary addressed modification of nucleic acids with the alkylating derivatives of oligothymidylate ethyl phosphotriesters. Effect of the phosphotriester fragments' configuration.

Abstract

The alkylating derivatives of four individual diastereomers of the oligonucleotide [dTp(Et)]3dTpU and two individual diastereomers of oligonucleotide [dTp(Et)dTp]4 have been synthesized. The reagents with the phosphorus atoms in the enantiomeric p" configuration are shown to be more efficient in reacting with poly(dA) and with nucleic acids in Krebs-2 ascites carcinoma cells compared to those with the phosphorus atoms in the p' configuration.

• Authors: T V Abramova, V V Vlassov, A V Lebedev, A S Ryte
• Journal: FEBS letters (FEBS Lett) Vol. 236 Issue 1 Pg. 243-5 (Aug 15 1988) ISSN: 0014-5793 [Print] England
• PMID: 2456955 (Publication Type: Journal Article)

Chemical References

• Oligodeoxyribonucleotides
• Organophosphates
• Organophosphorus Compounds
• RNA
• DNA

Topics

• Alkylation
• Animals
• Chemical Phenomena
• Chemistry
• DNA (metabolism)
• Kinetics
• Mice
• Oligodeoxyribonucleotides (metabolism)
• Organophosphates (metabolism)
• Organophosphorus Compounds (metabolism)
• RNA (metabolism)
• Tumor Cells, Cultured