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Acetate/acetyl-CoA metabolism associated with cancer fatty acid synthesis: overview and application.

Abstract
Understanding cancer-specific metabolism is important for identifying novel targets for cancer diagnosis and therapy. Induced acetate/acetyl CoA metabolism is a notable feature that is related to fatty acid synthesis supporting tumor growth. In this review, we focused on the recent findings related to cancer acetate/acetyl CoA metabolism. We also introduce [1-¹¹C]acetate positron emission tomography (PET), which is a useful tool to visualize up-regulation of acetate/acetyl CoA metabolism in cancer, and discuss the utility of [1-¹¹C]acetate PET in cancer diagnosis and its application to personalized medicine.
AuthorsYukie Yoshii, Takako Furukawa, Tsuneo Saga, Yasuhisa Fujibayashi
JournalCancer letters (Cancer Lett) Vol. 356 Issue 2 Pt A Pg. 211-6 (Jan 28 2015) ISSN: 1872-7980 [Electronic] Ireland
PMID24569091 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
CopyrightCopyright © 2014 Elsevier Ireland Ltd. All rights reserved.
Chemical References
  • Acetates
  • Fatty Acids
  • Acetyl Coenzyme A
  • Coenzyme A Ligases
  • acetate-CoA ligase (ADP-forming)
Topics
  • Acetates (metabolism)
  • Acetyl Coenzyme A (metabolism)
  • Cell Hypoxia
  • Coenzyme A Ligases (metabolism)
  • Fatty Acids (biosynthesis)
  • Humans
  • Lipogenesis (physiology)
  • Neoplasms (diagnosis, metabolism)
  • Positron-Emission Tomography (methods)
  • Precision Medicine
  • Up-Regulation

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