Non-association of IL-16 rs4778889 T/C polymorphism with cancer risk in Asians: a meta-analysis.

Abstract

The IL-16 rs4778889 T/C polymorphism is associated with cancer risk. However, the results are conflicting. We performed this meta-analysis to derive a more precise estimation of the relationship. A comprehensive literature search was performed using PubMed, Embase and Web of Science databases. Odds ratio (OR) and 95% confidence interval (CI) were used to assess the strength of association. A total of 6 studies including 1,603 cases and 2,342 controls were identified. With all studies involved, results showed no statistically significant association between IL-16 rs4778889 T/C polymorphism and cancer risk (CC vs. CT+TT: OR=0.74, 95%CI: 0.55-1.02, Ph=0.15; CC+CT vs. TT: OR=0.89, 95%CI: 0.72-1.10, Ph =0.03; CC vs. TT: OR=0.73, 95%CI: 0.53- 1.00, Ph =0.08; CT vs. TT: OR=0.91, 95%CI: 0.79-1.05, Ph =0.08; C vs. T: OR=0.89, 95%CI: 0.74-1.07, Ph =0.02). In addition, the results were not changed when studies were stratified by cancer type. However, to verify our findings, it is essential to perform more well-designed studies with larger sample sizes in the future.

• Authors: Lin-Lin Xu, Zhi-Chun Song, Kun Shang, Li-Qin Zhao, Zhan-Sheng Zhu
• Journal: Asian Pacific journal of cancer prevention : APJCP (Asian Pac J Cancer Prev) Vol. 15 Issue 2 Pg. 803-5 ( 2014) ISSN: 2476-762X [Electronic] Thailand
• PMID: 24568499 (Publication Type: Journal Article, Meta-Analysis)

Chemical References

• Interleukin-16

Topics

• Case-Control Studies
• Genetic Predisposition to Disease
• Humans
• Interleukin-16 (genetics)
• Neoplasms (genetics, pathology)
• Polymorphism, Genetic (genetics)
• Prognosis
• Risk Factors