Abstract | BACKGROUND: METHODS: In February 2013, we performed electronic searches in PubMed, EmBase, and the Cochrane Library to identify randomized controlled trials on cancer incidence, nonvascular death, and total mortality. Relative risk (RR) was used to measure the effect of omega-3 fatty acid supplementation on the risk of cancer incidence, nonvascular death, and total mortality using a random-effect model. The analysis was further stratified by factors that could affect the treatment effects. RESULTS: Of the 8,746 identified articles, we included 19 trials reporting data on 68,954 individuals. These studies reported 1,039 events of cancer, 2,439 events of nonvascular death, and 7,025 events of total mortality. Omega-3 fatty acid supplementation had no effect on cancer incidence (RR, 1.10; 95% CI: 0.97-1.24; P = 0.12), nonvascular death (RR, 1.00; 95% CI: 0.93-1.08; P = 1.00), or total mortality (RR, 0.95; 95% CI: 0.88-1.03; P = 0.24) when compared to a placebo. Subgroup analysis indicated that omega-3 fatty acid supplementation was associated with a reduction in total mortality risk if the proportion of men in the study population was more than 80%, or participants received alpha-linolenic acid. CONCLUSIONS:
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Authors | Yu-Fei Zhang, Hong-Fang Gao, An-Ji Hou, Yu-Hao Zhou |
Journal | BMC public health
(BMC Public Health)
Vol. 14
Pg. 204
(Feb 26 2014)
ISSN: 1471-2458 [Electronic] England |
PMID | 24568238
(Publication Type: Journal Article, Meta-Analysis)
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Chemical References |
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Topics |
- Dietary Supplements
- Fatty Acids, Omega-3
(administration & dosage)
- Humans
- Incidence
- Neoplasms
(epidemiology, mortality, prevention & control)
- Randomized Controlled Trials as Topic
- Risk Factors
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