OCT-1 overexpression is associated with poor prognosis in patients with well-differentiated gastric cancer.

Abstract

Octamer transcription factor-1 (OCT-1) is a well-known transcription factor that is reportedly overexpressed in intestinal metaplasia and gastric carcinoma in the intestine. In this study, we investigated OCT-1 overexpression as a prognostic factor for gastric cancer. The association between OCT-1 overexpression (detected using immunohistochemistry) and clinicopathological features including survival was evaluated. In vitro gain-of-function approaches were utilized to assess the function of OCT-1 in malignancy. Analysis of OCT-1 expression in patients with gastric cancer with well-differentiated carcinoma as per the World Health Organization classification showed that OCT-1 overexpression was correlated with advanced tumor invasion (58.8 % of patients with advanced tumor invasion vs. 21.2 % of patients with early tumor invasion; p<0.01), lymph node metastasis (63.9 % of patients with metastasis vs. 24.1 % of those without; p=0.015), and cancer recurrence (83.3 % of patients with recurrence vs. 25.4 % of those without; p<0.01), as well as a lower survival rate (62.8 vs. 87.9 Mo; p<0.01). However, there were no significant differences in the levels of OCT-1 expression in gastric cancer patients with other carcinoma types (p>0.05). Furthermore, we found that the proliferation rate of OCT-1-overexpressing MKN-45 cells was higher than that of the control cells. OCT-1 overexpression may be a marker for poor prognosis in patients with well-differentiated gastric adenocarcinoma.

• Authors: Sang-Ho Jeong, Young-Joon Lee, Bok-Im Cho, Woo-Song Ha, Sang-Kyung Choi, Eun-Jung Jung, Young-Tae Ju, Chi-Young Jeong, Gyung Hyuck Ko, Jiyun Yoo, Soon-Chan Hong
• Journal: Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine (Tumour Biol) Vol. 35 Issue 6 Pg. 5501-9 (Jun 2014) ISSN: 1423-0380 [Electronic] Netherlands
• PMID: 24566898 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• CDX2 Transcription Factor
• CDX2 protein, human
• Homeodomain Proteins
• Octamer Transcription Factor-1

Topics

• Aged
• CDX2 Transcription Factor
• Cell Line, Tumor
• Cell Movement
• Cell Proliferation
• Female
• Homeodomain Proteins (genetics)
• Humans
• Lymphatic Metastasis
• Male
• Middle Aged
• Neoplasm Invasiveness
• Octamer Transcription Factor-1 (analysis, genetics, physiology)
• Prognosis
• Stomach Neoplasms (chemistry, mortality, pathology)