Abstract | AIM: The aim of the present study was to evaluate the efficacy and safety of narrowband UVB (NB-UVB) compared with tacrolimus ointment 0.1% in patients with bilateral vitiligo. METHODS: In this comparative study, four groups of patients were randomized. Each group was composed by 12 patients with bilateral vitiligo; in each group, every patient was irradiated with NB-UVB (length: 311 nm) twice a week for 9 months and applied tacrolimus ointment 0.1% twice a day on the other area in the same period. Before starting therapy and after 3, 6 and 9 months of therapy, a clinical and photographic evaluation of percentage of repigmentation was performed and Dermatology Life Quality Index Questionnaire was fulfilled. RESULTS: A repigmentation at least partial occurred in 71% of patients after 36 weeks of treatment with tacrolimus ointment 0.1%; in the whole sample, 14 patients (29%) showed no repigmentation at all, with 2 of them discontinuing the therapy because of side effects ( erythema and folliculitis-like manifestations). A homogeneous repigmentation at least partial occurred in 69% of patients after 36 weeks of treatment with NB-UVB; in the whole sample 15 patients (31%) showed no repigmentation at all, with 1 of them discontinuing the therapy because of side effects. CONCLUSION:
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Authors | A Baldo, G Lodi, P Di Caterino, G Monfrecola |
Journal | Giornale italiano di dermatologia e venereologia : organo ufficiale, Societa italiana di dermatologia e sifilografia
(G Ital Dermatol Venereol)
Vol. 149
Issue 1
Pg. 123-30
(Feb 2014)
ISSN: 0392-0488 [Print] Italy |
PMID | 24566573
(Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial)
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Chemical References |
- Immunosuppressive Agents
- Tacrolimus
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Topics |
- Adolescent
- Adult
- Aged
- Child
- Epidermis
(pathology)
- Erythema
(etiology)
- Folliculitis
(etiology)
- Humans
- Immunosuppressive Agents
(therapeutic use)
- Melanocytes
(ultrastructure)
- Middle Aged
- Prospective Studies
- Skin Pigmentation
- Surveys and Questionnaires
- Tacrolimus
(therapeutic use)
- Ultraviolet Therapy
- Vitiligo
(complications, drug therapy, pathology, radiotherapy)
- Young Adult
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