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Ribonuclease binase decreases destructive changes of the liver and restores its regeneration potential in mouse lung carcinoma model.

Abstract
The successful application of exogenous ribonucleases of different origin to suppress tumor growth allows one to consider them as perspective therapeutics for treatment of oncological diseases. An important aspect of the success of an anti-cancer drug is low hepatotoxicity, which will reduce, if not eliminate entirely the undesirable side effects of treatment. Previously we have shown that ribonuclease from Bacillus intermedius (binase) exhibits high antitumor and antimetastatic activity in tumor models of different histological origin. In this work we studied hepatotoxic action of binase using mouse tumor model of Lewis lung carcinoma. Binase at doses of 0.1-1 mg/kg which produced effective suppression of tumor growth and metastasis, showed positive effect on the liver of tumor-bearing mice expressed in a significant reduction in the volume of destructive changes in the liver parenchyma and return to the normal level of the liver regenerative potential impaired due to endogenous intoxication and tumor burden.
AuthorsA V Sen'kova, N L Mironova, O A Patutina, V A Mitkevich, O V Markov, I Y Petrushanko, K M Burnysheva, M A Zenkova, A A Makarov
JournalBiochimie (Biochimie) Vol. 101 Pg. 256-9 (Jun 2014) ISSN: 1638-6183 [Electronic] France
PMID24565811 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
CopyrightCopyright © 2014 Elsevier Masson SAS. All rights reserved.
Chemical References
  • Antineoplastic Agents
  • Endoribonucleases
  • ribonuclease T(2)
Topics
  • Animals
  • Antineoplastic Agents (pharmacology, toxicity)
  • Carcinoma, Lewis Lung (drug therapy, pathology)
  • Endoribonucleases (pharmacology, toxicity)
  • Female
  • Liver (drug effects, pathology, physiopathology)
  • Liver Regeneration (drug effects)
  • Lung Neoplasms (drug therapy, secondary)
  • Mice, Inbred C57BL
  • Neoplasm Transplantation
  • Tumor Burden (drug effects)
  • Xenograft Model Antitumor Assays

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