Preliminary pharmacokinetics of PEGylated oxaliplatin polylactic acid nanoparticles in rabbits and tumor-bearing mice.

Abstract

To testify the targeting effect of PEGylated Oxaliplatin polylactic acid (OP-PEG-PLA) nanoparticles (NPs), we studied drug concentration in rabbit plasma and tissue distribution in tumor-bearing mice. Concentration of nanoparticle colloidal solution was performed with dialysis. Qualities of enriched NPs were characterized by particle size and drug content. OP concentration in samples was detected using ICP-MS. Compared to OP solution groups, OP concentration of NPs groups increased in the tumor (p < 0.05) and decreased in the kidney and heart (p < 0.05). Compared to OP-PLA NPs groups, OP concentration of OP-PEG-PLA NPs groups increased in the tumor and decreased in the liver and lung (p < 0.05). The concentrated OP-PEG-PLA NPs are good in clinical application and tumor delivery.

• Authors: Haitian Wei, Lisa Xu, Yong Sun, Gaohong Li, Zhaoyuan Cui, Guowen Yan, Qian Chen, Hongli Yin, Chao Ma
• Journal: Artificial cells, nanomedicine, and biotechnology (Artif Cells Nanomed Biotechnol) Vol. 43 Issue 4 Pg. 258-62 ( 2015) ISSN: 2169-141X [Electronic] England
• PMID: 24564351 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Drug Carriers
• Organoplatinum Compounds
• Polyesters
• Polymers
• Oxaliplatin
• Lactic Acid
• Polyethylene Glycols
• poly(lactide)
• polyethylene glycol 1000

Topics

• Animals
• Drug Carriers (chemistry, pharmacokinetics, pharmacology)
• Lactic Acid (chemistry, pharmacokinetics, pharmacology)
• Mice
• Nanoparticles (chemistry)
• Neoplasms, Experimental (drug therapy, pathology)
• Organoplatinum Compounds (chemistry, pharmacokinetics, pharmacology)
• Oxaliplatin
• Polyesters
• Polyethylene Glycols (chemistry, pharmacokinetics, pharmacology)
• Polymers (chemistry, pharmacokinetics, pharmacology)
• Rabbits