Abstract | OBJECTIVE:
Inflammation is now considered a main pathogenic factor in coronary atherosclerotic heart disease (CHD), and it has a positive correlation with plaque vulnerability. A novel anti-inflammatory factor, milk fat globule- epidermal growth factor 8 (MFG-E8), has been reported as having prominent anti-inflammatory effects in sepsis. However, few studies have reported on the association between MFG-E8 and CHD. In the present study, we aimed to investigate the serum MFG-E8 concentrations in patients with different stages of CHD or without CHD. Then, we studied the associations among MFG-E8, Gensini score, and high-sensitivity C-reactive protein ( hs-CRP) in Chinese patients with CHD to illustrate the role of MFG-E8 in CHD. METHODS: RESULTS: Compared with the controls, the CHD group had a lower level of MFG-E8 (673.20±112.34 ng/mL vs. 134.89±4.74 ng/mL, p<0.001). The level of serum MFG-E8 in the acute myocardial infarction group (118.07±10.10 ng/mL) was significantly less than that in the stable angina group (p=0.025). Further analysis showed that MFG-E8 had a negative association with the Gensini score and the hs-CRP level (r=-0.590, p<0.001; r=-0.105, p=0.022, respectively). In addition, multiple regression analysis of the association between MFG-E8 and the main cardiovascular risk factors in our cases showed that MFG-E8 had a negative association with hs-CRP and a positive association with LDL-c (all p<0.05). CONCLUSION: The serum level of MFG-E8 was negatively associated with the severity of coronary artery stenosis and the risk of clinical events. Thus, MFG-E8 has the potential to be a marker of vascular complications.
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Authors | Wen Dai, Yan Li, Yong-Nan Lv, Chuan-Dong Wei, Hong-Yun Zheng |
Journal | Atherosclerosis
(Atherosclerosis)
Vol. 233
Issue 2
Pg. 661-665
(Apr 2014)
ISSN: 1879-1484 [Electronic] Ireland |
PMID | 24561551
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2014 Elsevier Ireland Ltd. All rights reserved. |
Chemical References |
- Antigens, Surface
- Cholesterol, HDL
- Cholesterol, LDL
- MFGE8 protein, human
- Milk Proteins
- Triglycerides
- Fibrinogen
- C-Reactive Protein
- Cholesterol
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Topics |
- Angina Pectoris
(blood)
- Angina, Unstable
(blood)
- Antigens, Surface
(blood, physiology)
- C-Reactive Protein
(analysis)
- China
- Cholesterol
(blood)
- Cholesterol, HDL
(blood)
- Cholesterol, LDL
(blood)
- Coronary Angiography
- Coronary Artery Disease
(blood, diagnostic imaging)
- Diabetes Mellitus
(blood, epidemiology)
- Female
- Fibrinogen
(analysis)
- Humans
- Male
- Middle Aged
- Milk Proteins
(blood)
- Myocardial Infarction
(blood)
- Risk Factors
- Severity of Illness Index
- Sex Factors
- Smoking
(blood, epidemiology)
- Triglycerides
(blood)
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