Poisoning by organophosphorus
insecticides is a major global public health problem. Although
atropine has been widely used to treat
organophosphate (OP)
poisoning, sometimes atropinization cannot be achieved, even with high doses of
atropine. Hence, we aimed to assess the effect of
anisodamine for organophosphorus poisoned patients for whom atropinization could not be achieved through high doses of
atropine. In this study, sixty-four OP-
poisoning patients, all of whom accepted routine treatments but who did not attain atropinization after high doses of
atropine for 12 h, were enrolled. The result showed that the time to atropinization was 24.3±4.3 h in the
anisodamine group, significantly shorter than in the
atropine group (29.2±7.0 h, p<0.05); the
hospital stay in the
anisodamine group was 5.3±2.5 days, significantly shorter than the 6.9±2.3 days needed by the
atropine group (p<0.05). We draw a conclusion that
anisodamine can shorten the process of atropinization and
hospital stay in organophosphorus poisoned patients for whom atropinization cannot be achieved with high doses of
atropine.