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Efficiency of anisodamine for organophosphorus-poisoned patients when atropinization cannot be achieved with high doses of atropine.

Abstract
Poisoning by organophosphorus insecticides is a major global public health problem. Although atropine has been widely used to treat organophosphate (OP) poisoning, sometimes atropinization cannot be achieved, even with high doses of atropine. Hence, we aimed to assess the effect of anisodamine for organophosphorus poisoned patients for whom atropinization could not be achieved through high doses of atropine. In this study, sixty-four OP-poisoning patients, all of whom accepted routine treatments but who did not attain atropinization after high doses of atropine for 12 h, were enrolled. The result showed that the time to atropinization was 24.3±4.3 h in the anisodamine group, significantly shorter than in the atropine group (29.2±7.0 h, p<0.05); the hospital stay in the anisodamine group was 5.3±2.5 days, significantly shorter than the 6.9±2.3 days needed by the atropine group (p<0.05). We draw a conclusion that anisodamine can shorten the process of atropinization and hospital stay in organophosphorus poisoned patients for whom atropinization cannot be achieved with high doses of atropine.
AuthorsWei Wang, Quan-Fang Chen, Qi-Bin Li, Yan-Bin Wu, Kun Chen, Bo Chen, Jian-Mei Wen
JournalEnvironmental toxicology and pharmacology (Environ Toxicol Pharmacol) Vol. 37 Issue 2 Pg. 477-81 (Mar 2014) ISSN: 1872-7077 [Electronic] Netherlands
PMID24561530 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
CopyrightCopyright © 2013 Elsevier B.V. All rights reserved.
Chemical References
  • Antidotes
  • Insecticides
  • Solanaceous Alkaloids
  • anisodamine
  • Atropine
Topics
  • Adult
  • Antidotes (therapeutic use)
  • Atropine (therapeutic use)
  • Female
  • Humans
  • Insecticides (poisoning)
  • Male
  • Middle Aged
  • Organophosphate Poisoning (drug therapy)
  • Solanaceous Alkaloids (therapeutic use)

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