[Botulinum A toxin and detrusor sphincter dyssynergia: retrospective study of 47 patients].

Abstract

INTRODUCTION:

To assess the efficacy of injections of botulinum toxin type A (BT-A) in the urethral sphincter for treating detrusor sphincter dyssynergia (DSD).

PATIENTS AND METHODS:

Retrospective observational study of patients with confirmed urodynamic DSD (neurological and non-neurological etiologies) treated at our center from 2002 to 2010. All patients received 300 IU of DYSPORT® injected transperineally under electromyographic control. Using a visual analog scale (VAS) for mictional disorders and the measure of the post-void residual (PVR) as criteria of efficacy, results were classified as "non-satisfactory" (decrease in the VAS<2 or decrease in the PVR<20%), "intermediate" (decrease in the VAS≥2 or decrease in the PVR≥20%) or "satisfactory" (decrease in the VAS>3 or decrease in the PVR>40%).

RESULTS:

Records of 47 patients (7 women and 40 men) were studied. Mean follow-up was 14.2 months. At the end of follow-up, there were 23.4% (11) of "satisfactory" results, 19.1% (9) of "intermediate" results, 42.6% (20) of "non-satisfactory" results and 14.9% (7) of patients lost for follow-up. The mean decrease in PVR was 60 mL (from an average of 212 to an average of 152 mL). No side effect was observed.

CONCLUSION:

In this small series reporting the results of the injection of BT-A in the urethral sphincter for DSD, we observed 42.5% of satisfactory or intermediate results without associated side effects.

• Authors: H Habchi, J-P Galaup, N Morel-Journel, A Ruffion
• Journal: Progres en urologie : journal de l'Association francaise d'urologie et de la Societe francaise d'urologie (Prog Urol) Vol. 24 Issue 4 Pg. 234-9 (Mar 2014) ISSN: 1166-7087 [Print] France
• Vernacular Title: Toxine botulique A et dyssynergie vésico-sphinctérienne : étude rétrospective portant sur 47 patients.
• PMID: 24560292 (Publication Type: English Abstract, Journal Article, Observational Study)
• Copyright: Copyright © 2013 Elsevier Masson SAS. All rights reserved.

Chemical References

• Neuromuscular Agents
• Botulinum Toxins, Type A

Topics

• Adolescent
• Adult
• Aged
• Ataxia (drug therapy)
• Botulinum Toxins, Type A (therapeutic use)
• Female
• Humans
• Injections, Intralesional
• Male
• Middle Aged
• Neuromuscular Agents (therapeutic use)
• Retrospective Studies
• Urethra
• Urethral Diseases (drug therapy)
• Young Adult