Association of lipid profiles and the ratios with arterial stiffness in middle-aged and elderly Chinese.

Abstract

BACKGROUND:

Serum lipids and the ratios are known to be associated with the cardiovascular diseases (CVD). However, the associations of serum lipids and the ratios related to arterial stiffness are unclear. We sought to compare the strength of these serum lipids and the ratios with arterial stiffness assessing by brachial-ankle pulse wave velocity (baPWV) in the middle-aged and elderly Chinese subjects.

METHODS:

A total number of 1133 Chinese aged from 50 to 90 years old were recruited from Shanghai downtown district. The serum lipids, baPWV and major cardiovascular risk factors of the participants were measured.

RESULTS:

Participants with high baPWV exhibited higher levels of non-HDL-c, TC/HDL-c, TG/HDL-c, LDL-c/HDL-c, and non-HDL-c/HDL-c, while HDL-c worked in the opposite direction (all P<0.05). In addition, TC, TG, LDL-c, non-HDL-c, TC/HDL-c, TG/HDL-c, LDL-c/HDL-c, and non-HDL-c/HDL-c had a positive relationship with the baPWV value, while HDL-c was on the contrary (all P <0.05). Finally, individuals with high non-HDL-c/HDL-c (OR 1.71, 95% CI 1.06-2.55, P = 0.013) and low HDL-c (OR 0.57, 95% CI 0.35-0.96, P = 0.024) were seem to be at high risk of arterial stiffness.

CONCLUSIONS:

As a risk indicator, non-HDL-c/HDL-c, which could be readily obtained from routine serum lipids, was significantly associated with baPWV. Non-HDL-c/HDL-c was superior to traditional lipid variables for estimating arterial stiffness in the middle-aged and elderly Chinese population.

• Authors: Weiwei Zhao, Wei Gong, Nan Wu, Yintao Li, Kuanping Ye, Bin Lu, Zhaoyun Zhang, Shen Qu, Yiming Li, Yehong Yang, Renming Hu
• Journal: Lipids in health and disease (Lipids Health Dis) Vol. 13 Pg. 37 (Feb 20 2014) ISSN: 1476-511X [Electronic] England
• PMID: 24555711 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Cholesterol, HDL
• Cholesterol, LDL
• Lipids
• Cholesterol

Topics

• Aged
• Aged, 80 and over
• Arteries (pathology)
• Asian People
• China
• Cholesterol (blood)
• Cholesterol, HDL (blood)
• Cholesterol, LDL (blood)
• Female
• Humans
• Lipids (blood)
• Male
• Middle Aged
• Vascular Stiffness (physiology)