Comparative MRI analysis of morphologic patterns of bile duct disease in IgG4-related systemic disease versus primary sclerosing cholangitis.

Abstract

OBJECTIVE:

The purpose of this study was to perform a retrospective MRI-based comparative analysis of the morphologic patterns of bile duct disease in IgG4-related systemic disease (ISD, also called autoimmune pancreatitis) compared with primary sclerosing cholangitis (PSC) and the autoimmune liver diseases autoimmune hepatitis and primary biliary cirrhosis.

MATERIALS AND METHODS:

This study included 162 consecutively registered patients (47 with ISD, 73 with PSC, and 42 with autoimmune liver diseases). Two abdominal radiologists retrospectively reviewed MR images in consensus. Imaging findings on the bile ducts, liver, pancreas, and other organs were analyzed to establish disease patterns.

RESULTS:

ISD was associated with contiguous thickening of intrahepatic and extrahepatic bile ducts (p<0.001), pancreatic parenchymal abnormalities (p<0.001), renal abnormalities (p<0.001), and gallbladder wall thickening (p<0.03). The severity of common bile duct wall thickness was significantly different in ISD (p<0.001). The mean single wall thickness in the ISD group was 3.00 (SD, 1.47) mm, in the PSC group was 1.89 (SD, 0.73) mm, and in the autoimmune liver disease group was 1.80 (SD, 0.67) mm. PSC was associated with liver parenchymal abnormalities (p<0.001). We did not find statistical significance between the three groups in location (p=0.220) or length (p=0.703) of extrahepatic bile duct strictures, enhancement of bile duct stricture (p=0.033), upper abdominal lymphadenopathy, or retroperitoneal fibrosis. Although presence of intrahepatic bile duct stricture was statistically significant when all three groups were compared, it was not useful for differentiating ISD from PSC.

CONCLUSION:

The presence of continuous as opposed to skip disease in the bile ducts, gallbladder involvement, and single-wall common bile duct thickness greater than 2.5 mm supports a diagnosis of ISD over PSC. ISD and PSC could not be differentiated on the basis of location and length of common bile duct stricture.

• Authors: Ajay Tokala, Korosh Khalili, Ravi Menezes, Gideon Hirschfield, Kartik S Jhaveri
• Journal: AJR. American journal of roentgenology (AJR Am J Roentgenol) Vol. 202 Issue 3 Pg. 536-43 (Mar 2014) ISSN: 1546-3141 [Electronic] United States
• PMID: 24555589 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Immunoglobulin G

Topics

• Adult
• Autoimmune Diseases (complications, immunology, pathology)
• Bile Duct Diseases (complications, pathology)
• Cholangitis, Sclerosing (pathology)
• Diagnosis, Differential
• Female
• Humans
• Immunoglobulin G (immunology)
• Magnetic Resonance Imaging (methods)
• Male
• Middle Aged
• Reproducibility of Results
• Sensitivity and Specificity