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Drug-induced myotonia in human intercostal muscle.

Abstract
The myotonia-inducing effects of furosemide and clofibrate, two widely used pharmaceutical agents, were investigated in excised human external intercostal muscle. The effects of anthracene-9-carboxylic acid (9-AC), a well-known myotonia-producing chemical, were also tested for comparison. In the presence of these drugs the electrical threshold was lowered, and a constant current pulse produced multiple spiking. Short trains of direct stimuli were often followed by after-activity, and this caused a myotonia-like prolongation of muscle contraction. Voltage-clamp experiments showed that 0.05 mM anthracene-9-carboxylic acid, 1 mM furosemide, and 1 mM clofibrate decreased the chloride conductance of the muscle fiber membrane to 14, 18, and 40%, respectively, of the normal value, and the myotonia-inducing potency of the 3 drugs was correlated with the decreased chloride conductance. The potassium currents were not affected by these compounds.
AuthorsH Kwieciński, F Lehmann-Horn, R Rüdel
JournalMuscle & nerve (Muscle Nerve) Vol. 11 Issue 6 Pg. 576-81 (Jun 1988) ISSN: 0148-639X [Print] United States
PMID2455224 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Anthracenes
  • Chlorides
  • Ion Channels
  • 9-anthroic acid
  • Furosemide
  • Clofibrate
Topics
  • Anthracenes (pharmacology)
  • Chlorides (metabolism)
  • Clofibrate (pharmacology)
  • Furosemide (pharmacology)
  • Humans
  • In Vitro Techniques
  • Intercostal Muscles (drug effects)
  • Ion Channels (drug effects)
  • Muscle Contraction (drug effects)
  • Myotonia (chemically induced)

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