Abstract |
The objective was to develop a stable, reproducible and patient non-infringing novel transdermal drug delivery system "nano-carrier transdermal gel" (NCTG) in combination of partial dose replacement of diclofenac diethylamine ( DDEA) by curcumin (CRM). The drug content of gel was 99.30 and 97.57% for DDEA and CRM. Plasma samples were analyzed by liquid chromatography with triple-quadrupole tandem mass spectrometer (LC-MS/MS). Data were integrated with Analyst™ and analyzed by WinNonlin; stability parameters were analyzed using Tukey-Kramer multiple comparison test. Its average skin irritation scored 0.49 concluded to be non- irritant, safe for human use and in vivo studies revealed significantly greater extent of absorption and highly significant inhibition (%) of carrageenan induced paw edema. The results also demonstrated that encapsulation of drugs in nano-carrier increases its biological activity due to superior skin penetration potential. Hence, a novel once day transdermal gel of nano-carrier (nano-transfersomes; deformable vesicular) is achieved, to increase systemic availability, subsequent reduction in dose and toxicity of DDEA was developed for the treatment of inflammation.
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Authors | Hema Chaudhary, Kanchan Kohli, Vikash Kumar |
Journal | International journal of pharmaceutics
(Int J Pharm)
Vol. 465
Issue 1-2
Pg. 175-86
(Apr 25 2014)
ISSN: 1873-3476 [Electronic] Netherlands |
PMID | 24548719
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2014 Elsevier B.V. All rights reserved. |
Chemical References |
- Acrylates
- Anti-Inflammatory Agents
- Drug Carriers
- Drug Combinations
- Gels
- Diclofenac
- Carrageenan
- Curcumin
- carbopol 934P
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Topics |
- Acrylates
(chemistry)
- Administration, Cutaneous
- Animals
- Anti-Inflammatory Agents
(administration & dosage, blood, chemistry, pharmacokinetics, toxicity)
- Biological Availability
- Carrageenan
- Chemistry, Pharmaceutical
- Chromatography, Liquid
- Curcumin
(administration & dosage, chemistry, pharmacokinetics, toxicity)
- Diclofenac
(administration & dosage, blood, chemistry, pharmacokinetics, toxicity)
- Disease Models, Animal
- Drug Administration Schedule
- Drug Carriers
- Drug Combinations
- Drug Stability
- Gels
- Inflammation
(chemically induced, prevention & control)
- Male
- Nanoparticles
- Nanotechnology
- Rats, Wistar
- Skin
(drug effects, pathology)
- Skin Irritancy Tests
- Tandem Mass Spectrometry
- Technology, Pharmaceutical
(methods)
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