Translating DRiPs: MHC class I immunosurveillance of pathogens and tumors.

Abstract

MHC class I molecules display oligopeptides on the cell surface to enable T cell immunosurveillance of intracellular pathogens and tumors. Speed is of the essence in detecting viruses, which can complete a full replication cycle in just hours, whereas tumor detection is typically a finding-the-needle-in-the-haystack exercise. We review current evidence supporting a nonrandom, compartmentalized selection of peptidogenic substrates that focuses on rapidly degraded translation products as a main source of peptide precursors to optimize immunosurveillance of pathogens and tumors.

• Authors: Luis C Antón, Jonathan W Yewdell
• Journal: Journal of leukocyte biology (J Leukoc Biol) Vol. 95 Issue 4 Pg. 551-62 (Apr 2014) ISSN: 1938-3673 [Electronic] United States
• PMID: 24532645 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)

Chemical References

• DRIP, VDR interacting protein complex
• Histocompatibility Antigens Class I
• Mediator Complex

Topics

• Animals
• Antigen Presentation
• Histocompatibility Antigens Class I (immunology)
• Humans
• Mediator Complex
• Monitoring, Immunologic
• Neoplasms (immunology)
• Protein Biosynthesis
• Ribosomes (immunology)