Oxaliplatin induces hypomyelination and reduced neuregulin 1 expression in the rat sciatic nerve.

Abstract

Oxaliplatin causes severe peripheral neuropathy. In this study, we examined hypomyelination in the peripheral nerve in oxaliplatin-induced neuropathy rat model. Gene expression of neuregulin 1 (NRG1), a myelination regulatory factor, is reduced in the dorsal root ganglion (DRG) in DNA microarray analysis. Oxaliplatin increased the g-ratio and reduced levels of myelin protein zero in sciatic nerve, suggesting the hypomyelination. Moreover, oxaliplatin reduced NRG1 mRNA levels in the DRG and decreased levels of cleaved NRG1 type III protein in the sciatic nerve. Our results indicate that oxaliplatin induces hypomyelination and reduced NRG1 expression.

• Authors: Kuniaki Tsutsumi, Yuji Yamashita, Soichiro Ushio, Takehiro Kawashiri, Takanori Kaname, Shunsuke Fujita, Ryozo Oishi, Nobuaki Egashira
• Journal: Neuroscience research (Neurosci Res) Vol. 80 Pg. 86-90 (Mar 2014) ISSN: 1872-8111 [Electronic] Ireland
• PMID: 24530887 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2014 Elsevier Ireland Ltd and the Japan Neuroscience Society. All rights reserved.

Chemical References

• Antineoplastic Agents
• Myelin Proteins
• Neuregulin-1
• Organoplatinum Compounds
• RNA, Messenger
• Oxaliplatin

Topics

• Animals
• Antineoplastic Agents (pharmacology)
• Axons (pathology)
• Ganglia, Spinal (drug effects, metabolism)
• Gene Expression Profiling
• Gene Expression Regulation (drug effects)
• Male
• Myelin Proteins (genetics, metabolism)
• Neuregulin-1 (genetics, metabolism)
• Oligonucleotide Array Sequence Analysis
• Organoplatinum Compounds (pharmacology)
• Oxaliplatin
• Polyradiculoneuropathy (chemically induced, metabolism, pathology)
• RNA, Messenger (metabolism)
• Rats
• Rats, Sprague-Dawley
• Sciatic Nerve (drug effects, metabolism, pathology)
• Time Factors