Abstract |
The experiment was carried out on Wistar rats receiving orally either oil or oily solution of methylbromophenvinfos ( Polfos) either in a single dose of 0.5 LD50, or doses of 0.1 LD50 once daily for a period of 2, 4 or 6 weeks. The activities of cholinesterase (ChE), beta-glucuronidase (beta-glu), lipase and amylase were assayed in the blood serum, the activity of acetylcholinesterase (AChE)-in brain homogenates, and the activities of lipase and amylase-in homogenates of the pancreas. Cholinesterases were inhibited in the course of both acute and chronic poisoning with Polfos. During the acute poisoning a sharp increase in the activity of beta-glu in the blood serum, 1 and 2 h after the pesticide administration, was observed. Polfos inhibited lipase and amylase both after acute and chronic treatment.
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Authors | D Pawłowska, D Koćmierska-Grodzka, J Moniuszko-Jakoniuk |
Journal | Polish journal of pharmacology and pharmacy
(Pol J Pharmacol Pharm)
1987 Jul-Aug
Vol. 39
Issue 4
Pg. 361-70
ISSN: 0301-0244 [Print] Poland |
PMID | 2453047
(Publication Type: Journal Article)
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Chemical References |
- Enzymes
- Insecticides
- methylbromfenvinphos
- Lipase
- Cholinesterases
- Amylases
- Glucuronidase
- Chlorfenvinphos
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Topics |
- Amylases
(blood, metabolism)
- Animals
- Brain
(enzymology)
- Chlorfenvinphos
(analogs & derivatives, toxicity)
- Cholinesterases
(blood, metabolism)
- Enzymes
(blood)
- Female
- Glucuronidase
(blood, metabolism)
- Insecticides
(toxicity)
- Lipase
(blood, metabolism)
- Male
- Pancreas
(enzymology)
- Rats
- Rats, Inbred Strains
- Time Factors
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