[Evaluation of the concordance between biological markers and clinical activity in inflammatory bowel disease].

Abstract

BACKGROUND AND OBJECTIVES:

Endoscopy is the gold standard to assess disease severity in inflammatory bowel disease, although it is an invasive procedure. Clinical activity and biological markers have been routinely used to determine disease activity in a non-invasive manner. The aim of this study was to determine concordance between common biological markers (C reactive protein, orosomucoid, erythrocyte sedimentation rate, fibrinogen, platelets, leukocytes, neutrophils and haemoglobin) and clinical activity in inflammatory bowel disease.

PATIENTS AND METHOD:

Consecutive patients with inflammatory bowel disease were included. Clinical activity was evaluated according to the Harvey-Bradshaw index in Crohn's disease and to the partial Mayo score in ulcerative colitis. Serum concentrations of the different biomarkers were analysed. Concordance between clinical activity and elevation of the serological biomarkers was determined using the kappa statistic.

RESULTS:

In total, 350 patients were included (median age 46 years, Crohn's disease 59%). Eleven percent of patients had clinical activity. Crohn's disease patients had mild clinical activity in 44% of cases, moderate disease in 44% and only 12% of patients had severe clinical activity. In ulcerative colitis, patients had mild, moderate and severe clinical activity in 50, 42 and 8% of cases, respectively. None of the biomarkers included had an acceptable concordance with clinical activity (kappa statistic ≤ 0.30).

CONCLUSIONS:

Concordance between serological biomarkers and clinical activity in inflammatory bowel disease is remarkably low.

• Authors: Pablo Miranda García, María Chaparro, Javier P Gisbert
• Journal: Medicina clinica (Med Clin (Barc)) Vol. 144 Issue 1 Pg. 9-13 (Jan 06 2015) ISSN: 1578-8989 [Electronic] Spain
• Vernacular Title: Concordancia entre la actividad clínica y los marcadores biológicos en la enfermedad inflamatoria intestinal.
• PMID: 24530050 (Publication Type: Evaluation Study, Journal Article, Observational Study)
• Copyright: Copyright © 2013 Elsevier España, S.L.U. All rights reserved.

Chemical References

• Biomarkers
• Hemoglobins
• Orosomucoid
• Fibrinogen
• C-Reactive Protein

Topics

• Adult
• Biomarkers (blood)
• Blood Cell Count
• Blood Sedimentation
• C-Reactive Protein (analysis)
• Endoscopy, Digestive System
• Female
• Fibrinogen (analysis)
• Hemoglobins (analysis)
• Humans
• Inflammatory Bowel Diseases (blood, diagnosis, pathology)
• Male
• Middle Aged
• Orosomucoid (analysis)
• Predictive Value of Tests
• Prospective Studies
• Severity of Illness Index